Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 4/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.37 |
| ▸ | SMO | Q99835 | 1/20 | 0.37 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 2/20 | 0.37 |
| ▸ | SYK | P43405 | 2/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.37 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.37 |
| ▸ | FES | P07332 | 1/20 | 0.36 |
| ▸ | FER | P16591 | 1/20 | 0.36 |
| ▸ | FRK | P42685 | 1/20 | 0.36 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.36 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 2/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL428720 | 0.81 | TYK2 (0.49) | PIK3CAPIK3CGPIK3CBMAPK14SMO | |
| SCHEMBL5483800 | 0.81 | PIK3CA (0.47) | PIK3CAPIK3CGPIK3CBGRM4MAPK14 | |
| SCHEMBL426412 | 0.81 | PIK3CA (0.45) | PIK3CAPIK3CGPIK3CBGRM4MAPK14 | |
| SCHEMBL427331 | 0.80 | GRM4 (0.45) | PIK3CAPIK3CGPIK3CBGRM4MAPK14 | |
| SCHEMBL427044 | 0.79 | PIK3CA (0.44) | PIK3CAPIK3CGPIK3CBGRM4MAPK14 | |
| SCHEMBL430156 | 0.77 | PIK3CA (0.44) | PIK3CAPIK3CGPIK3CBGRM4MAPK14 | |
| SCHEMBL427231 | 0.77 | NPC1 (0.44) | PIK3CAPIK3CGPIK3CBGRM4MAPK14 | |
| SCHEMBL425757 | 0.76 | PIK3CA (0.46) | PIK3CAPIK3CGPIK3CBNAPEPLDTYK2 | |
| SCHEMBL425546 | 0.76 | PIK3CA (0.41) | PIK3CAPIK3CGPIK3CBGRM4MAPK14 | |
| SCHEMBL426413 | 0.76 | PIK3CA (0.47) | PIK3CAPIK3CGPIK3CBNAPEPLDTYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120021434-A1 | METHOD FOR TREATING B CELL REGULATED AUTOIMMUNE DISORDERS | SYNTA PHARMACEUTICALS CORP. (US) | 2012-01-26 | — | — | US | disclosed |