Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 2/20 | 0.50 |
| ▸ | TTK | P33981 | 11/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 3/20 | 0.42 |
| ▸ | BTK | Q06187 | 3/20 | 0.42 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.41 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CCND2 | P30279 | 1/20 | 0.41 |
| ▸ | CCND3 | P30281 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1018567 | 0.82 | PTK2 (0.50) | PTK2TTKEGFRJAK3BTK | |
| SCHEMBL1074127 | 0.82 | PTK2 (0.50) | PTK2TTKEGFRJAK3BTK | |
| SCHEMBL1017917 | 0.80 | PTK2 (0.56) | PTK2TTKJAK3BTKHRH4 | |
| SCHEMBL1018447 | 0.79 | PTK2 (0.55) | PTK2TTKJAK3BTKHRH4 | |
| SCHEMBL1018554 | 0.77 | PTK2 (0.50) | PTK2TTKEGFRJAK3BTK | |
| SCHEMBL1017060 | 0.77 | AKT2 (0.54) | PTK2TTKJAK3BTKHRH4 | |
| SCHEMBL1018487 | 0.75 | PBK (0.52) | PTK2TTKJAK3BTKHRH4 | |
| SCHEMBL1018558 | 0.72 | PTK2 (0.57) | PTK2EGFRJAK3BTKPAK4 | |
| SCHEMBL27930633 | 0.70 | PTK2 (0.52) | PTK2TTKEGFRJAK3BTK | |
| SCHEMBL1018231 | 0.69 | PTK2 (0.58) | PTK2TTKEGFRJAK3BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271631-A2 | INHIBITORS OF PROTEIN KINASES | Portola Pharmaceuticals, Inc. (US) | 2011-01-12 | — | — | EP | claimed |
| WO-2009131687-A2 | INHIBITORS OF PROTEIN KINASES | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-10-29 | — | — | WO | claimed |