Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 4/20 | 0.57 |
| ▸ | JAK3 | P52333 | 5/20 | 0.53 |
| ▸ | BTK | Q06187 | 3/20 | 0.53 |
| ▸ | PAK4 | O96013 | 3/20 | 0.50 |
| ▸ | SYK | P43405 | 2/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1018554 | 0.78 | PTK2 (0.50) | PTK2JAK3BTKSYKEGFR | |
| SCHEMBL1018484 | 0.78 | PTK2 (0.59) | PTK2JAK3BTKPAK4SYK | |
| SCHEMBL12082697 | 0.77 | PTK2 (0.55) | PTK2JAK3BTKPAK4SYK | |
| SCHEMBL1018231 | 0.76 | PTK2 (0.58) | PTK2JAK3BTKPAK4SYK | |
| SCHEMBL1018234 | 0.76 | PTK2 (0.58) | PTK2JAK3BTKPAK4SYK | |
| SCHEMBL1017177 | 0.76 | PTK2 (0.58) | PTK2JAK3BTKPAK4SYK | |
| SCHEMBL1018487 | 0.75 | PBK (0.52) | PTK2JAK3BTKPAK4SYK | |
| SCHEMBL1018336 | 0.74 | ROCK2 (0.52) | PAK4 | |
| SCHEMBL1074127 | 0.74 | PTK2 (0.50) | PTK2JAK3BTKPAK4EGFR | |
| SCHEMBL1018567 | 0.74 | PTK2 (0.50) | PTK2JAK3BTKPAK4EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271631-A2 | INHIBITORS OF PROTEIN KINASES | Portola Pharmaceuticals, Inc. (US) | 2011-01-12 | — | — | EP | disclosed |
| WO-2009131687-A2 | INHIBITORS OF PROTEIN KINASES | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-10-29 | — | — | WO | disclosed |