Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 10/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.37 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.37 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2657038 | 0.89 | PTGS2 (0.42) | BRD4PTGS2PTGS1SLC6A4PTGDR2 | |
| SCHEMBL2657019 | 0.87 | PTGS2 (0.41) | BRD4PTGS2PTGS1SLC6A4PTGDR2 | |
| SCHEMBL2668333 | 0.85 | PTGS2 (0.42) | BRD4PTGS2PTGS1SLC6A4PTGDR2 | |
| SCHEMBL2668334 | 0.80 | GPR6 (0.41) | BRD4PTGS2PTGS1 | |
| SCHEMBL2656912 | 0.80 | GPR6 (0.41) | BRD4PTGS2PTGS1 | |
| SCHEMBL2655760 | 0.78 | GCK (0.38) | BRD4PTGS2PTGS1PTGDR2 | |
| SCHEMBL2656733 | 0.78 | KMT2A (0.45) | BRD4PTGS2 | |
| SCHEMBL2656198 | 0.77 | GCK (0.50) | — | |
| SCHEMBL2656341 | 0.77 | NPC1 (0.40) | BRD4PTGS2 | |
| SCHEMBL2655672 | 0.77 | BRD4 (0.49) | BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125735-B1 | 2,2,2-TRI-SUBSTITUTED ACETAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS, THEIR PROCESS AND PHARMACEUTICAL APPLICATION | ADVINUS THERAPEUTICS PRIVATE LTD (IN) | 2012-06-27 | — | — | EP | disclosed |