PTGS2

Prostaglandin G/H synthase 2 · P35354 · PTGS2 on Sugi Atlas →

700,144 patent compounds predicted against PTGS2, 398,598 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Etoricoxib (SCHEMBL4680)	1.00	20/20
Glucametacin (SCHEMBL24511)	0.72	20/20
Deracoxib (SCHEMBL24645)	1.00	19/20
Valdecoxib (SCHEMBL3356)	1.00	17/20
Loxoprofen (SCHEMBL24423)	1.00	17/20
Proglumetacin (SCHEMBL27106)	0.59	17/20
Acemetacin (SCHEMBL23843)	1.00	16/20
SCHEMBL24512	0.65	15/20
Celecoxib (SCHEMBL3708)	1.00	14/20
Terofenamate (SCHEMBL26088)	0.70	14/20
SCHEMBL19751	0.49	14/20
Rofecoxib (SCHEMBL3050)	1.00	13/20
Meclofenamic Acid (SCHEMBL3504)	1.00	13/20
Oxametacin (SCHEMBL24552)	0.85	12/20
Lumiracoxib (SCHEMBL4479)	1.00	11/20
Parecoxib (SCHEMBL9529)	1.00	11/20
SCHEMBL19456	0.64	11/20
Indomethacin (SCHEMBL9300)	1.00	9/20
SCHEMBL7751	0.57	9/20
SCHEMBL20194	0.41	9/20

Clinical trials — most relevant to PTGS2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Type 2 Diabetes Mellitus and Atherosclerosis	PHASE4	UNKNOWN
Addition of Aspirin to Standard of Care in Oral Cancer	PHASE2/PHASE3	COMPLETED
European Celecoxib Trial in Primary Breast Cancer	PHASE3	COMPLETED
Assessment of the Response to Etoricoxib in Patients With Ankylosing Spondylitis and Inadequate Response to ≥2 NSAIDs	PHASE3	COMPLETED
Selective COX-II Inhibitor as an Adjuvant Therapy in Patients With Resectable Advanced Stomach Cancer ( Histological Staging ≥ T2N1) - A Multi-Centre Prospective Randomised Controlled Trial	PHASE3	UNKNOWN
Selective COX-II Inhibitor as a Palliative Therapy in Patients With R1 or R2 Resection for Disseminated Stomach Cancer - A Multi-Centre Prospective Randomized Controlled Trial	PHASE3	UNKNOWN
Aspirin and Renal Disease Progression in Patients With Type 2 Diabetes	PHASE3	UNKNOWN
Effect of Selective COX-2 Inhibition on Ulcer Healing	PHASE3	COMPLETED
Efficacy of Ibuprofen Chronotherapy in Healing After Surgical Extraction of the Mandibular Third Molar	PHASE2/PHASE3	UNKNOWN
Chemoprevention Trial in Familial Adenomatous Polyposis (FAP) Coli Using EPA	PHASE2/PHASE3	COMPLETED
Ramatroban/Montelukast Versus Montelukast/Placebo on the Early Allergic Reaction in Asthma Sensitive to House Dust Mite	PHASE2/PHASE3	WITHDRAWN
Ibuprofen Versus Acetaminophen for Treatment of Mild Traumatic Brain Injury	PHASE2	WITHDRAWN
Evaluation of Response to Use of Intravesical Ozone Gas in Interstitial Cystitis /Bladder Pain Syndrome	PHASE2	UNKNOWN
Celebrex for Pain Relief After Oral Surgery	PHASE2	COMPLETED
Comparision Between Paracetamol and Ibuprofen in Closure of Patent Ductus Arteriosus	PHASE2	UNKNOWN
Changes in Breast Cancer Biomarkers Using Synergistic Prostaglandin Inhibitors	PHASE1/PHASE2	COMPLETED
Adjunctive Celecoxib in Childhood-onset OCD Study	PHASE2	UNKNOWN
Phase II A Trial of Curcumin Among Patients With Prevalent Subclinical Neoplastic Lesions (Aberrant Crypt Foci)	PHASE2	COMPLETED
Prostanoid Levels After Medication to Prevent Pain Following Third Molar (Wisdom Tooth) Extraction	PHASE2	COMPLETED
Vitamin E Supplements in Preventing Cancer in Patients at Risk of Prostate Cancer or Who Have Prostate Cancer	PHASE1	COMPLETED
Clinical Research of the Prognostic Influence of NSAIDS's Anti-inflammatory Effect on Senior Patients With Hip Fracture	nan	UNKNOWN
Lipidomics Screening of Celecoxib in ex Vivo Human Whole Blood Assay - Part B	nan	COMPLETED
Lipidomics Screening of Anti-inflammatory Drugs and Drug Candidates in Vitro - Part A	nan	ACTIVE_NOT_RECRUITING
Urinary PGE-MUM (PROSTAGLANDIN E-MAJOR URINARY METABOLITE) as Inflammatory Marker in Chronic Inflammatory Bowel Disease	nan	COMPLETED
The Role of Lymphangiogenesis in Head and Neck Cancer Metastasis	nan	UNKNOWN
Association and Mechanism Between Cyclooxygenase-2 and Interleukin-6 in Gastric Cancer	nan	UNKNOWN
Palmitoylethanolamide in Ulcerative Colitis	nan	NOT_YET_RECRUITING
Study About Patients Using Copper Intrauterine Device	nan	COMPLETED
OrthoCor Advanced Trial for Knee Osteoarthritis	nan	COMPLETED
Effect of Perioperative IV Ibuprofen on Cerebral Oxygenation and Postoperative Cognition During One-Lung Ventilation	nan	NOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a PTGS2 binder may also engage these)

Protein	Name	Similarity
Q05769	—	1.000	Q05769 →
P27607	—	1.000	P27607 →
P35355	—	1.000	P35355 →
O62698	—	1.000	O62698 →
P79208	—	1.000	P79208 →
P70682	—	1.000	P70682 →
O62725	—	1.000	O62725 →
O19183	—	1.000	O19183 →
O62664	—	0.999	O62664 →
O02768	—	0.999	O02768 →
P05979	—	0.997	P05979 →
Q8HZR1	—	0.994	Q8HZR1 →
Q63921	—	0.993	Q63921 →
O97554	—	0.992	O97554 →
PTGS1	Prostaglandin G/H synthase 1	0.992	landscape →
P22437	—	0.991	P22437 →
O61213	—	0.984	O61213 →
P82600	—	0.981	P82600 →
Q9C9U3	—	0.978	Q9C9U3 →
Q9VEG6	—	0.977	Q9VEG6 →
Q4WY82	—	0.974	Q4WY82 →
P81732	—	0.974	P81732 →
G4N4J5	—	0.974	G4N4J5 →
P40126	—	0.974	P40126 →
Q95119	—	0.973	Q95119 →
P12031	—	0.973	P12031 →
P29812	—	0.973	P29812 →
A0A1B2CTB9	—	0.973	A0A1B2CTB9 →
F9FAJ9	—	0.972	F9FAJ9 →
P80960	—	0.972	P80960 →