Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.57 |
| ▸ | BTK | Q06187 | 6/20 | 0.57 |
| ▸ | AURKB | Q96GD4 | 12/20 | 0.53 |
| ▸ | AURKA | O14965 | 6/20 | 0.53 |
| ▸ | PLK4 | O00444 | 5/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 5/20 | 0.53 |
| ▸ | ABL1 | P00519 | 5/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.53 |
| ▸ | INSR | P06213 | 5/20 | 0.53 |
| ▸ | FYN | P06241 | 5/20 | 0.53 |
| ▸ | CSF1R | P07333 | 5/20 | 0.53 |
| ▸ | LYN | P07948 | 5/20 | 0.53 |
| ▸ | MET | P08581 | 5/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.53 |
| ▸ | SRC | P12931 | 5/20 | 0.53 |
| ▸ | FLT1 | P17948 | 5/20 | 0.53 |
| ▸ | RPS6KB1 | P23443 | 5/20 | 0.53 |
| ▸ | EPHA2 | P29317 | 5/20 | 0.53 |
| ▸ | BLK | P51451 | 5/20 | 0.53 |
| ▸ | NEK2 | P51955 | 5/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18611146 | 0.84 | BTK (0.56) | KDRBTKAURKBAURKAPLK4 | |
| SCHEMBL14643163 | 0.83 | KDR (0.60) | KDRBTKAURKBAURKAPLK4 | |
| SCHEMBL18590958 | 0.81 | KDR (0.58) | KDRBTKAURKBAURKAPLK4 | |
| SCHEMBL17034035 | 0.80 | KDR (0.57) | KDRBTKAURKBAURKAPLK4 | |
| SCHEMBL6925932 | 0.79 | BTK (0.54) | KDRBTKAURKBAURKAPLK4 | |
| SCHEMBL6927094 | 0.76 | BTK (0.56) | KDRBTKAURKBAURKAPLK4 | |
| SCHEMBL20006918 | 0.75 | KDR (0.72) | KDRBTKAURKBAURKAPLK4 | |
| SCHEMBL6924514 | 0.75 | EPHB4 (0.58) | KDRBTKCYP3A4 | |
| SCHEMBL6924755 | 0.70 | EPHB4 (0.35) | KDRBTKAURKBAURKAPLK4 | |
| SCHEMBL10198708 | 0.70 | BTK (0.57) | BTKMETALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3112351-B1 | NAPHTHYLAMIDE COMPOUND, PREPARATION METHOD AND USE THEREOF | SHANGHAI INST MATERIA MEDICA CAS (CN) | 2022-03-30 | — | — | EP | disclosed |
| EP-2549868-B1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2015-01-07 | — | — | EP | disclosed |
| US-20130018038-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2013-01-17 | — | — | US | disclosed |
| US-20120077828-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2012-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130018038-A1 | CHEMICAL COMPOUNDS | BRCA1, IRS1, IGF1R | KDR 3297/4885BTK 2336/4885AURKB 2752/4885 |
| US-20120077828-A1 | CHEMICAL COMPOUNDS | BRCA1, IRS1, IGF1R | KDR 3297/4885BTK 2336/4885AURKB 2752/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.