Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.72 |
| ▸ | AURKB | Q96GD4 | 12/20 | 0.72 |
| ▸ | AURKA | O14965 | 7/20 | 0.72 |
| ▸ | MAP4K4 | O95819 | 7/20 | 0.72 |
| ▸ | ABL1 | P00519 | 7/20 | 0.72 |
| ▸ | NTRK1 | P04629 | 7/20 | 0.72 |
| ▸ | INSR | P06213 | 7/20 | 0.72 |
| ▸ | FYN | P06241 | 7/20 | 0.72 |
| ▸ | LYN | P07948 | 7/20 | 0.72 |
| ▸ | MET | P08581 | 7/20 | 0.72 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.72 |
| ▸ | SRC | P12931 | 7/20 | 0.72 |
| ▸ | BLK | P51451 | 7/20 | 0.72 |
| ▸ | STK3 | Q13188 | 7/20 | 0.72 |
| ▸ | NTRK2 | Q16620 | 7/20 | 0.72 |
| ▸ | TAOK1 | Q7L7X3 | 7/20 | 0.72 |
| ▸ | PLK4 | O00444 | 6/20 | 0.72 |
| ▸ | CSF1R | P07333 | 6/20 | 0.72 |
| ▸ | FLT1 | P17948 | 6/20 | 0.72 |
| ▸ | RPS6KB1 | P23443 | 6/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19996024 | 0.79 | KDR (1.00) | KDRAURKBAURKAMAP4K4ABL1 | |
| SCHEMBL14643163 | 0.78 | KDR (0.60) | KDRAURKBAURKAMAP4K4ABL1 | |
| SCHEMBL18590958 | 0.76 | KDR (0.58) | KDRAURKBAURKAMAP4K4ABL1 | |
| SCHEMBL10198705 | 0.75 | KDR (0.57) | KDRAURKBAURKAMAP4K4ABL1 | |
| SCHEMBL17034035 | 0.75 | KDR (0.57) | KDRAURKBAURKAMAP4K4ABL1 | |
| SCHEMBL3528912 | 0.73 | BTK (0.61) | KDRAURKBAURKAMAP4K4ABL1 | |
| SCHEMBL3378132 | 0.73 | BTK (0.67) | KDRAURKBAURKAMAP4K4ABL1 | |
| SCHEMBL5474567 | 0.72 | KDR (0.66) | KDRAURKBAURKAMAP4K4ABL1 | |
| SCHEMBL4821973 | 0.72 | KDR (0.80) | KDRAURKBAURKAMAP4K4ABL1 | |
| SCHEMBL4827643 | 0.72 | KDR (0.80) | KDRAURKBAURKAMAP4K4ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018058098-A1 | COMPOUNDS AND METHODS FOR TREATING OR PREVENTING ALZHEIMER'S DISEASE | YALE UNIVERSITY (US) | 2018-03-29 | — | — | WO | disclosed |