Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | TP53 | P04637 | 3/20 | 0.58 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | ACP1 | P24666 | 1/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | PDE5A | O76074 | 1/20 | 0.44 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29559492 | 0.83 | FLT1 (0.56) | MAPTPOLBLMNAHTTAPP | |
| SCHEMBL29558367 | 0.81 | APP (0.47) | MAPTTP53LMNAAPPEGFR | |
| SCHEMBL29558864 | 0.80 | APP (0.63) | POLBAPPEGFRPDE5A | |
| SCHEMBL29559506 | 0.80 | MEN1 (0.59) | MAPTLMNAAPPMAPK1EGFR | |
| SCHEMBL29558267 | 0.80 | LMNA (0.56) | MAPTTP53LMNAAPPMAPK1 | |
| SCHEMBL29558270 | 0.79 | APP (0.48) | MAPTPOLBLMNAHTTSLC2A1 | |
| SCHEMBL4018007 | 0.79 | TYMS (0.59) | MAPTTP53PIK3CDACP1PIK3CA | |
| SCHEMBL29558471 | 0.78 | FLT1 (0.50) | MAPTPOLBLMNAHTTAPP | |
| SCHEMBL189609 | 0.77 | PIK3CD (0.81) | MAPTTP53PIK3CDPOLBPIK3CA | |
| SCHEMBL6996100 | 0.77 | PIK3CA (0.55) | MAPTTP53PIK3CDPOLBPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012006552-A1 | COMBINATIONS OF KINASE INHIBITORS FOR THE TREATMENT OF CANCER | EXELIXIS, INC. (US) | 2012-01-12 | — | — | WO | disclosed |