SCHEMBL10200217

SCHEMBL10200217

CC(C)(C)OC(=O)Nc1ccc2cc(Br)ccc2c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 1/20 0.47
CA1 P00915 1/20 0.47
CA9 Q16790 1/20 0.47
KAT6A Q92794 1/20 0.46
KMT2A Q03164 3/20 0.44
MEN1 O00255 2/20 0.44
RXFP1 Q9HBX9 1/20 0.44
PRNP P04156 1/20 0.44
NPC1 O15118 1/20 0.43
RECQL P46063 1/20 0.43
RAB9A P51151 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
CYP17A1 P05093 2/20 0.43
HDAC3 O15379 1/20 0.43
HDAC1 Q13547 1/20 0.43
HDAC2 Q92769 1/20 0.43
HDAC8 Q9BY41 1/20 0.43
HDAC6 Q9UBN7 1/20 0.43
KDM4E B2RXH2 1/20 0.43
LMNA P02545 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30452006 1.00 CA12 (0.47) CA12CA1CA9KAT6AKMT2A
SCHEMBL3403454 0.84 KAT6A (0.60) CA12CA1CA9KAT6AKMT2A
SCHEMBL30216106 0.84 KAT6A (0.60) CA12CA1CA9KAT6AKMT2A
SCHEMBL467281 0.84 KMT2A (0.56) KMT2AMEN1NPC1RECQLRAB9A
SCHEMBL23158879 0.83 KAT6A (0.50) CA12CA1CA9KAT6ARXFP1
SCHEMBL4672586 0.82 NPC1 (0.50) CA12CA1CA9KAT6AKMT2A
SCHEMBL12599766 0.82 CA12 (0.47) CA12CA1CA9KAT6AKMT2A
SCHEMBL22804523 0.82 CA12 (0.47) CA12CA1CA9KAT6ANPC1
SCHEMBL20932800 0.82 MEN1 (0.47) CA12CA1CA9KAT6AKMT2A
SCHEMBL23484531 0.82 CA12 (0.47) CA12CA1CA9KAT6AKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109020820-B Preparation method of 6-bromo-2-aminonaphthalene 杭州惠诺医药科技有限公司 2021-06-25 CN claimed
CN-109020820-B Preparation method of 6-bromo-2-aminonaphthalene 杭州惠诺医药科技有限公司 2021-06-25 CN disclosed
EP-2601188-B1 HEPATITIS C VIRUS INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2017-10-18 EP disclosed
EP-3022185-B1 PESTICIDE COMPOUNDS BASF SE (DE) 2017-09-06 EP disclosed
EP-2513091-B1 HEPATITIS C VIRUS INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2017-04-12 EP disclosed
US-9497970-B2 Pesticide compounds BASF SE (DE) 2016-11-22 US disclosed
US-20160157491-A1 Pesticide Compounds BASF SE (DE) 2016-06-09 US disclosed
EP-3022185-A1 PESTICIDE COMPOUNDS BASF SE (DE) 2016-05-25 EP disclosed
WO-2015007682-A1 PESTICIDE COMPOUNDS BASF SE (DE) 2015-01-22 WO disclosed
US-8809548-B2 Hepatitis C virus inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2014-08-19 US disclosed
WO-2011075607-A1 NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION INTERMUNE, INC. (US) 2011-06-23 WO disclosed
US-20110152246-A1 NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION INTERMUNE, INC. (US) 2011-06-23 US disclosed
WO-2011075439-A1 HEPATITIS C VIRUS INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2011-06-23 WO disclosed
WO-2010096302-A1 HEPATITIS C VIRUS INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2010-08-26 WO disclosed
US-20100215616-A1 Hepatitis C Virus Inhibitors BRISTOL-MYERS SQUIBB COMPANY 2010-08-26 US disclosed
US-20100215616-A1 Hepatitis C Virus Inhibitors BRISTOL-MYERS SQUIBB COMPANY 2010-08-26 US disclosed
US-7498068-B2 Liquid-crystal aligning agent, liquid-crystal alignment film comprising the same, and liquid-crystal element NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2009-03-03 US disclosed
US-7498068-B2 Liquid-crystal aligning agent, liquid-crystal alignment film comprising the same, and liquid-crystal element NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2009-03-03 US disclosed
US-20070224370-A1 Liquid-Crystal Aligning Agent, Liquid-Crystal Alignment Film Comprising the Same, and Liquid-Crystal Element NISSAN CHEMICALS INDUSTRIES, LTD. (JP) 2007-09-27 US disclosed
US-20070224370-A1 Liquid-Crystal Aligning Agent, Liquid-Crystal Alignment Film Comprising the Same, and Liquid-Crystal Element NISSAN CHEMICALS INDUSTRIES, LTD. (JP) 2007-09-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100215616-A1 Hepatitis C Virus Inhibitors HAVCR2, PYGL, HCCS CA12 3169/4885CA1 4434/4885CA9 3974/4885
US-20160157491-A1 Pesticide Compounds C1R, C1S, CBR3 CA12 3117/4885CA1 1110/4885CA9 844/4885
US-20110152246-A1 NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION EIF2AK2, HAVCR2, IRF3 CA12 4538/4885CA1 4777/4885CA9 4186/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.