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PYGL

Glycogen phosphorylase, liver form · P06737 · PYGL on Sugi Atlas →

39,887 patent compounds predicted against PYGL, 19,694 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Ingliforib Ingliforib (SCHEMBL122709) 0.74 17/20
SCHEMBL1156511 SCHEMBL1156511 0.44 17/20
SCHEMBL741419 SCHEMBL741419 0.49 16/20
SCHEMBL740197 SCHEMBL740197 0.48 16/20
SCHEMBL763907 SCHEMBL763907 0.52 14/20
SCHEMBL763943 SCHEMBL763943 0.60 13/20
SCHEMBL739706 SCHEMBL739706 0.43 13/20
SCHEMBL721512 SCHEMBL721512 0.48 12/20
SCHEMBL1156078 SCHEMBL1156078 0.46 12/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL742545) 0.45 12/20
SCHEMBL716921 SCHEMBL716921 0.53 11/20
SCHEMBL315402 SCHEMBL315402 0.53 11/20
SCHEMBL315403 SCHEMBL315403 0.53 11/20
SCHEMBL310396 SCHEMBL310396 0.50 11/20
SCHEMBL739788 SCHEMBL739788 0.49 11/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL741745) 0.48 11/20
SCHEMBL256052 SCHEMBL256052 0.46 11/20
SCHEMBL835828 SCHEMBL835828 0.45 11/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL741648) 0.54 10/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL741649) 0.54 10/20

Clinical trials — most relevant to PYGL by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Acute Effects of an Oral Fat Load on Skeletal Muscle and Hepatic Insulin Sensitivity PHASE4COMPLETED
Alpelisib, Fulvestrant and Dapagliflozin for the Treatment of HR+, HER2 -, PIK3CA Mutant Metastatic Breast Cancer PHASE2UNKNOWN
A Double-Blind, Placebo-Controlled Study of Fermented Deglycyrrhizinated Licorice Extract PHASE2COMPLETED
Liver Glycogen and Hypoglycemia in Humans PHASE1ACTIVE_NOT_RECRUITING
Effect of Meal Timing in T2D on Hepatocytes SRIT1 and Clock Genes nanUNKNOWN
Role of the Liver in Glucose Homeostasis Using Metabolic Imaging nanCOMPLETED
Effects of Polyphenols Found in Pomegranate and Olives Food Supplements on Postprandial Blood Glucose in Vivo. nanCOMPLETED
Effects of Polyphenols Found in Pomegranate Juice on Postprandial Blood Glucose in Vivo nanCOMPLETED
Non Invasive Assessment of Liver Glycogen Kinetics and ATP Synthesis in Type1 Diabetics nanCOMPLETED
The Effects of Citric and Malic Acid Found in Pomegranate Juice on Glycaemic Response to White Bread. nanCOMPLETED
Effect of a Beverage Comprised of Compounds From Olives on Post-prandial Blood Glucose Responses in Healthy Volunteers nanCOMPLETED
Effects of Dual-Source Carbohydrate Intake and Liver Glycogen Repletion After Overnight Fasting. nanNOT_YET_RECRUITING
Hepatic Glycogen and Fat Oxidation nanCOMPLETED
Effect of an Polyphenolic Beverage in Healthy Volunteers nanACTIVE_NOT_RECRUITING
Liver Glycogen Dynamics nanCOMPLETED
The Study of HIV Protease Inhibitors and Their Effects on Glucose Metabolism nanCOMPLETED
Effects of Carbohydrase-inhibiting Polyphenols on Glycaemic Response in Vivo nanCOMPLETED
The Role of Sugars in Fat Accumulation in the Liver nanRECRUITING
Investigation of Acute Physiological Effects of Aspiration Therapy nanCOMPLETED
Evaluation of the Neuro-endocrine Response to Post-prandial Hyperinsulinaemic Hypoglycaemia. nanCOMPLETED
Prevention of Hypoglycaemia by Oral 40% Destrogel nanCOMPLETED
Impact of Physical Activity on Blood Glucose Stability and Energy Stores in Individuals With Type 1 Diabetes nanCOMPLETED
Evaluation of the Effect of Hypoglycemia With PET and a Norepinephrine Transporter Ligand nanCOMPLETED
Effect of Roux-en-Y Gastric Bypass or Gastric Sleeve Surgery on Type 2 Diabetes nanCOMPLETED
Hepatic Energy Fluxes in NASH and NAS Patients nanACTIVE_NOT_RECRUITING
Steviol Glycoside for Use in Restoring Muscle Glycogen by Increasing the Rate of Glycogen Re-synthesis in Muscles nanUNKNOWN
The Effect of Oral Carbohydrate Administration on Postoperative Well-being nanCOMPLETED
Insulin Resistance in Relation to Hyperthyroidism and Hypothyroidism nanUNKNOWN
Safety Study of Repeated Doses of Glucagon on Animal Starch in the Liver nanCOMPLETED
Effect of Acute Fructose Load in Human nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a PYGL binder may also engage these)

ProteinNameSimilarity
P09811 — 1.000 P09811 →
Q0VCM4 — 1.000 Q0VCM4 →
Q5MIB5 — 1.000 Q5MIB5 →
Q9ET01 — 1.000 Q9ET01 →
P45180 — 1.000 P45180 →
O84250 — 1.000 O84250 →
P79334 — 1.000 P79334 →
PYGB Glycogen phosphorylase, brain form 1.000 landscape →
P0AC87 — 1.000 P0AC87 →
Q5R5M6 — 1.000 Q5R5M6 →
Q8CI94 — 1.000 Q8CI94 →
Q00766 — 1.000 Q00766 →
Q9PKE6 — 1.000 Q9PKE6 →
P06738 — 1.000 P06738 →
Q5MIB6 — 0.999 Q5MIB6 →
Q9Z8N1 — 0.999 Q9Z8N1 →
P00489 — 0.999 P00489 →
P53537 — 0.999 P53537 →
PYGM Glycogen phosphorylase, muscle form 0.999 landscape →
P53534 — 0.999 P53534 →
P0AC86 — 0.999 P0AC86 →
O18751 — 0.998 O18751 →
Q8HXW4 — 0.998 Q8HXW4 →
Q9XTL9 — 0.998 Q9XTL9 →
P09812 — 0.997 P09812 →
Q3B7M9 — 0.997 Q3B7M9 →
P32811 — 0.997 P32811 →
Q9LKJ3 — 0.996 Q9LKJ3 →
P27472 — 0.996 P27472 →
Q9WUB3 — 0.995 Q9WUB3 →