⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1663037 | 0.80 | MEN1 (0.45) | — | |
| SCHEMBL17508623 | 0.80 | MEN1 (0.42) | — | |
| SCHEMBL31599691 | 0.77 | MEN1 (0.40) | — | |
| SCHEMBL14764041 | 0.77 | MEN1 (0.43) | — | |
| SCHEMBL10174579 | 0.77 | — | — | |
| SCHEMBL22980532 | 0.76 | L3MBTL1 (0.44) | — | |
| SCHEMBL5928297 | 0.76 | MEN1 (0.39) | — | |
| SCHEMBL19011387 | 0.76 | MEN1 (0.42) | — | |
| SCHEMBL174144 | 0.76 | — | — | |
| SCHEMBL31579078 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12459925-B2 | Sulphonyl urea derivatives as NLRP3 inflammasome modulators | NodThera Limited (GB) | 2025-11-04 | — | — | US | disclosed |
| US-20250333424-A1 | ANTIVIRAL COMPOUNDS | GILEAD SCIENCES, INC. | 2025-10-30 | — | — | US | disclosed |
| EP-3728238-B1 | SULPHONYL UREA DERIVATIVES AS NLRP3 INFLAMMASOME MODULATORS | NODTHERA LTD (GB) | 2025-06-18 | — | — | EP | disclosed |
| CN-119241539-A | Pyrazolo piperidine (ketone) -containing derivative, and preparation method and application thereof | 沈阳药科大学 | 2025-01-03 | — | — | CN | disclosed |
| US-20240368129-A1 | SULPHONYL UREA DERIVATIVES AS NLRP3 INFLAMMASOME MODULATORS | NodThera Limited (GB) | 2024-11-07 | — | — | US | disclosed |
| CN-116396205-B | N-aryl indole derivative and preparation method and application thereof | 沈阳药科大学 | 2024-10-01 | — | — | CN | disclosed |
| US-12012397-B2 | Sulphonyl urea derivatives as NLRP3 inflammasome modulators | NodThera Limited (GB) | 2024-06-18 | — | — | US | disclosed |
| CN-116396205-A | N-aryl indole derivative and preparation method and application thereof | 沈阳药科大学 | 2023-07-07 | — | — | CN | disclosed |
| US-20230145050-A1 | SULPHONYL UREA DERIVATIVES AS NLRP3 INFLAMMASOME MODULATORS | NodThera Limited (GB) | 2023-05-11 | — | — | US | disclosed |
| US-11518757-B2 | Sulphonyl urea derivatives as NLRP3 inflammasome modulators | NodThera Limited (GB) | 2022-12-06 | — | — | US | disclosed |
| CN-111954670-A | Sulfonylurea derivatives as NLRP3 inflammasome modulators | 诺瑟拉有限公司 | 2020-11-17 | — | — | CN | disclosed |
| EP-3728238-A1 | SULPHONYL UREA DERIVATIVES AS NLRP3 INFLAMMASOME MODULATORS | Nodthera Limited (GB) | 2020-10-28 | — | — | EP | disclosed |
| US-8569336-B2 | Compounds for the treatment of inflammatory disorders | TONG LING (US) | 2013-10-29 | — | — | US | disclosed |
| US-8569336-B2 | Compounds for the treatment of inflammatory disorders | TONG LING (US) | 2013-10-29 | — | — | US | disclosed |
| US-8450355-B2 | Compounds for the treatment of inflammatory diseases | MERCK SHARP & DOHME CORP. (US) | 2013-05-28 | — | — | US | disclosed |
| US-8450355-B2 | Compounds for the treatment of inflammatory diseases | MERCK SHARP & DOHME CORP. (US) | 2013-05-28 | — | — | US | disclosed |
| US-20120015926-A1 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | TONG LING (US) | 2012-01-19 | — | — | US | disclosed |
| US-20120015926-A1 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | TONG LING (US) | 2012-01-19 | — | — | US | disclosed |
| US-20110288077-A1 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISEASES | SCHERING CORPORATION (US) | 2011-11-24 | — | — | US | disclosed |
| US-20110288077-A1 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISEASES | SCHERING CORPORATION (US) | 2011-11-24 | — | — | US | disclosed |