Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | PARP15 | Q460N3 | 3/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 3/20 | 0.44 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.44 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ACACB | O00763 | 2/20 | 0.41 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12886697 | 0.90 | PARP15 (0.46) | MEN1KMT2APARP15PARP10PARP2 | |
| SCHEMBL765403 | 0.85 | ACACB (0.47) | PARP15PARP10PARP2ADAM17HPGD | |
| SCHEMBL12886067 | 0.78 | CYP4F2 (0.54) | PARP15PARP10PARP2ADAM17HPGD | |
| SCHEMBL14534755 | 0.76 | PARP15 (0.53) | MEN1KMT2APARP15PARP10PARP2 | |
| SCHEMBL12886453 | 0.75 | HPGD (0.58) | MEN1KMT2APARP15PARP10PARP2 | |
| SCHEMBL18873511 | 0.73 | HPGD (0.44) | MEN1KMT2ASLC6A3HPGDACACB | |
| SCHEMBL17835255 | 0.73 | ALDH1A1 (0.43) | MEN1KMT2AALDH1A1 | |
| SCHEMBL12086465 | 0.72 | CYP4F2 (0.51) | PARP15PARP10PARP2ACACBCYP4F2 | |
| SCHEMBL7783907 | 0.72 | ALDH1A1 (0.38) | MEN1KMT2AALDH1A1 | |
| SCHEMBL3685282 | 0.72 | PARP15 (0.54) | PARP15PARP10PARP2ADAM17HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094643-B1 | N-((3-BENZYL)-2,2-(BIS-PHENYL)-PROPAN-1-AMINE DERIVATIVES AS CETP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROSIS AND CARDIOVASCULAR DISEASES | BRISTOL MYERS SQUIBB CO (US) | 2012-02-29 | — | — | EP | disclosed |
| WO-2008070496-A2 | N- ( (3-BENZYL) -2, 2- (BIS-PHENYL) -PROPAN-1-AMINE DERIVATIVES AS CETP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROSIS AND CARDIOVASCULAR DISEASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-06-12 | — | — | WO | disclosed |