Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 1/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 2/20 | 0.34 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10210780 | 0.88 | CHRNB4 (0.55) | CHRNB4CHRNA3TSHRSSTR5 | |
| SCHEMBL10210781 | 0.85 | CRBN (0.45) | CHRNB4CHRNA3CYP2D6CYP2C9TSHR | |
| SCHEMBL10168575 | 0.83 | CHRNB4 (0.40) | CHRNB4CHRNA3USP2CYP2D6HSD17B10 | |
| SCHEMBL10211559 | 0.79 | CHRNB4 (0.41) | CHRNB4CHRNA3CYP2D6CYP2C9PKM | |
| SCHEMBL10210782 | 0.78 | CHRNB4 (0.38) | CHRNB4CHRNA3USP2CYP2D6CYP2C9 | |
| SCHEMBL3084584 | 0.72 | CYP2C9 (0.49) | CHRNB4CHRNA3USP2CYP2C9TSHR | |
| SCHEMBL10168605 | 0.71 | CHRNB4 (0.52) | CHRNB4CHRNA3CYP2D6HTR2BSSTR5 | |
| SCHEMBL3089912 | 0.71 | TDP1 (0.40) | CHRNB4CHRNA3USP2CYP2D6CYP2C9 | |
| SCHEMBL938967 | 0.70 | CHRNB4 (0.37) | CHRNB4CHRNA3USP2CYP2D6CYP2C9 | |
| SCHEMBL14534188 | 0.70 | CHRNB4 (0.53) | CHRNB4CHRNA3HTR2BSSTR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120082702-A1 | NICOTINAMIDE COMPOUNDS USEFUL AS KINASE MODULATORS | BRISTOL-MEYERS SQUIBB COMPANY | 2012-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120082702-A1 | NICOTINAMIDE COMPOUNDS USEFUL AS KINASE MODULATORS | NADK, BTK, NAMPT | CHRNB4 2625/4885CHRNA3 2203/4885USP2 4786/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.