Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.57 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.52 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10210729 | 0.88 | USP30 (0.70) | USP30CHEK1PIK3CDDRD2DRD4 | |
| SCHEMBL10212160 | 0.83 | NPC1 (0.69) | USP30CHEK1NPC1RAB9AMAPK1 | |
| SCHEMBL10210831 | 0.82 | USP30 (0.60) | USP30CHEK1PIK3CDDRD2DRD4 | |
| SCHEMBL10212633 | 0.81 | USP30 (0.56) | USP30CHEK1PIK3CDDRD2DRD4 | |
| SCHEMBL10212606 | 0.81 | USP30 (0.59) | USP30CHEK1DRD2DRD4NPC1 | |
| SCHEMBL4356360 | 0.81 | CTSL (0.57) | USP30CHEK1HDAC4HDAC6PDGFRB | |
| SCHEMBL10210847 | 0.81 | CTSL (0.57) | USP30CHEK1HDAC4HDAC6PDGFRB | |
| SCHEMBL10211667 | 0.81 | USP30 (0.55) | USP30CHEK1DRD2DRD4NPC1 | |
| SCHEMBL10211606 | 0.80 | SMYD3 (0.59) | USP30CHEK1NPC1RAB9AHDAC4 | |
| SCHEMBL10210732 | 0.80 | NPC1 (0.51) | USP30CHEK1NPC1RAB9AHDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120082702-A1 | NICOTINAMIDE COMPOUNDS USEFUL AS KINASE MODULATORS | BRISTOL-MEYERS SQUIBB COMPANY | 2012-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120082702-A1 | NICOTINAMIDE COMPOUNDS USEFUL AS KINASE MODULATORS | NADK, BTK, NAMPT | SMYD2 3985/4885USP30 4807/4885CHEK1 490/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.