Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.70 |
| ▸ | NPC1 | O15118 | 7/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.47 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10211634 | 0.89 | NPC1 (0.55) | RAB9ANPC1SMN1; SMN2HTTTSHR | |
| SCHEMBL10210841 | 0.84 | RAB9A (0.65) | RAB9ANPC1SMN1; SMN2HTTTSHR | |
| SCHEMBL10210750 | 0.84 | EPHX2 (0.60) | RAB9ANPC1SMN1; SMN2HTTTSHR | |
| SCHEMBL10212192 | 0.84 | NPC1 (0.68) | RAB9ANPC1SMN1; SMN2HTTTSHR | |
| SCHEMBL10210838 | 0.84 | NPC1 (0.70) | RAB9ANPC1SMN1; SMN2TSHREPHX2 | |
| SCHEMBL2751372 | 0.84 | RAB9A (0.97) | RAB9ANPC1SMN1; SMN2HTTTSHR | |
| SCHEMBL10211642 | 0.83 | NPC1 (0.51) | RAB9ANPC1SMN1; SMN2HTTTSHR | |
| SCHEMBL18735757 | 0.83 | RAB9A (1.00) | RAB9ANPC1SMN1; SMN2HTTTSHR | |
| SCHEMBL24381741 | 0.82 | EPHX1 (0.66) | RAB9ANPC1SMN1; SMN2EPHX2GAA | |
| SCHEMBL10211627 | 0.82 | EPHX1 (0.66) | RAB9ANPC1SMN1; SMN2EPHX2EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120082702-A1 | NICOTINAMIDE COMPOUNDS USEFUL AS KINASE MODULATORS | BRISTOL-MEYERS SQUIBB COMPANY | 2012-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120082702-A1 | NICOTINAMIDE COMPOUNDS USEFUL AS KINASE MODULATORS | NADK, BTK, NAMPT | RAB9A 1841/4885NPC1 1778/4885SMN1; SMN2 2328/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.