Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 13/20 | 0.60 |
| ▸ | GSK3B | P49841 | 4/20 | 0.52 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.52 |
| ▸ | PLK4 | O00444 | 3/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.52 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.52 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.52 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.52 |
| ▸ | PRKCG | P05129 | 3/20 | 0.52 |
| ▸ | CDK1 | P06493 | 3/20 | 0.52 |
| ▸ | PRKACA | P17612 | 3/20 | 0.52 |
| ▸ | CDK2 | P24941 | 3/20 | 0.52 |
| ▸ | MARK3 | P27448 | 3/20 | 0.52 |
| ▸ | AKT2 | P31751 | 3/20 | 0.52 |
| ▸ | FLT4 | P35916 | 3/20 | 0.52 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.52 |
| ▸ | GSK3A | P49840 | 3/20 | 0.52 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10269404 | 0.86 | MAPKAPK2 (0.60) | MAPKAPK2GSK3BCDK5DYRK1APLK4 | |
| SCHEMBL13201333 | 0.85 | GSK3B (0.58) | MAPKAPK2GSK3BCDK5DYRK1AMAPK13 | |
| SCHEMBL10213517 | 0.83 | MAPKAPK2 (0.60) | MAPKAPK2GSK3BCDK5DYRK1APLK4 | |
| SCHEMBL10269156 | 0.83 | MAPKAPK2 (0.57) | MAPKAPK2GSK3BCDK5DYRK1APLK4 | |
| SCHEMBL10213534 | 0.83 | MAPKAPK2 (0.55) | MAPKAPK2GSK3BCDK5DYRK1APLK4 | |
| SCHEMBL760551 | 0.82 | MAPKAPK2 (0.71) | MAPKAPK2GSK3BCDK5DYRK1APLK4 | |
| SCHEMBL10213393 | 0.82 | MAPKAPK2 (0.56) | MAPKAPK2GSK3BCDK5DYRK1APLK4 | |
| SCHEMBL758279 | 0.81 | MAPKAPK2 (0.53) | MAPKAPK2GSK3BCDK5DYRK1APLK4 | |
| SCHEMBL759934 | 0.81 | MAPKAPK2 (0.53) | MAPKAPK2GSK3BCDK5DYRK1APLK4 | |
| SCHEMBL10213473 | 0.81 | MAPKAPK2 (0.57) | MAPKAPK2GSK3BCDK5DYRK1APLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120053345-A1 | Indazole Compounds | ABBOTT LABORATORIES (US) | 2012-03-01 | — | — | US | disclosed |
| US-20120053345-A1 | Indazole Compounds | ABBOTT LABORATORIES (US) | 2012-03-01 | — | — | US | disclosed |
| US-8008481-B2 | Indazole compounds | ABBVIE INC. | 2011-08-30 | — | — | US | disclosed |
| US-8008481-B2 | Indazole compounds | ABBVIE INC. | 2011-08-30 | — | — | US | disclosed |
| US-20070282101-A1 | Indazole compounds | ABBVIE INC. | 2007-12-06 | — | — | US | disclosed |
| US-20070282101-A1 | Indazole compounds | ABBVIE INC. | 2007-12-06 | — | — | US | disclosed |
| WO-2007117465-A2 | INDAZOLE COMPOUNDS | ABBOTT LABORATORIES (US) | 2007-10-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070282101-A1 | Indazole compounds | CYP3A43, CYP3A7, UGT1A1 | MAPKAPK2 1905/4885GSK3B 1016/4885CDK5 1473/4885 |
| US-20120053345-A1 | Indazole Compounds | CYP3A43, CYP3A7, UGT1A1 | MAPKAPK2 1905/4885GSK3B 1016/4885CDK5 1473/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.