Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 18/20 | 0.60 |
| ▸ | CRBN | Q96SW2 | 18/20 | 0.60 |
| ▸ | IKZF3 | Q9UKT9 | 3/20 | 0.60 |
| ▸ | TNF | P01375 | 2/20 | 0.60 |
| ▸ | IL1B | P01584 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.32 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18900402 | 0.92 | DDB1 (0.60) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL18945872 | 0.90 | DDB1 (0.75) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL283241 | 0.90 | DDB1 (0.75) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL18904277 | 0.90 | DDB1 (0.75) | DDB1CRBNIKZF3TNFIL1B | |
| Hydrochloric Acid SCHEMBL284302 | 0.89 | DDB1 (0.74) | DDB1CRBNIKZF3TNFIL1B | |
| Hydrochloric Acid SCHEMBL284301 | 0.88 | DDB1 (0.72) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL18900455 | 0.86 | CRBN (0.80) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL18900401 | 0.81 | CRBN (0.49) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL25475645 | 0.81 | DDB1 (0.74) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL14218469 | 0.81 | DDB1 (0.74) | DDB1CRBNIKZF3TNFIL1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2420498-B1 | 5-substituted quinazolinone derivatives as anti-cancer agents | CELGENE CORP (US) | 2017-05-31 | — | — | EP | disclosed |
| EP-2420498-A1 | 5-substituted quinazolinone derivatives as anti-cancer agents | Celgene Corporation (US) | 2012-02-22 | — | — | EP | disclosed |