Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 3/20 | 0.42 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL574873 | 0.81 | BRAF (0.42) | BRAFMAPK3MAPK1MAPK13CSNK1D | |
| SCHEMBL27908264 | 0.71 | BRAF (0.40) | BRAFMAPK3MAPK1MAPK13CSNK1D | |
| SCHEMBL15192238 | 0.71 | CYP17A1 (0.40) | BRAFMAPK3MAPK1 | |
| SCHEMBL15192043 | 0.71 | PIK3CA (0.43) | BRAF | |
| SCHEMBL27908263 | 0.71 | BRAF (0.36) | BRAFMAPK3MAPK1MAPK13CSNK1D | |
| SCHEMBL17836530 | 0.70 | BRAF (0.34) | BRAFMAPK3MAPK1MAPK13CSNK1D | |
| SCHEMBL574898 | 0.70 | BRD4 (0.45) | BRAF | |
| SCHEMBL1847759 | 0.70 | BRAF (0.40) | BRAFMAPK3MAPK1MAPK13CSNK1D | |
| SCHEMBL2050662 | 0.69 | BRAF (0.44) | BRAFMAPK3MAPK1MAPK13CSNK1D | |
| SCHEMBL24950777 | 0.69 | BRAF (0.57) | BRAFMAPK3MAPK1MAPK13CSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012016993-A1 | DERIVATIVES OF PYRAZOLOPHENYL-BENZENESULFONAMIDE COMPOUNDS AND USE THEREOF AS ANTITUMOR AGENTS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-02-09 | — | — | WO | disclosed |