Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 4/20 | 0.36 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | CCNC | P24863 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.32 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.32 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.32 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.32 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15192238 | 0.77 | CYP17A1 (0.40) | BRAFMAPK3MAPK1IRAK4CYP2D6 | |
| SCHEMBL27908264 | 0.77 | BRAF (0.40) | BRAFMAPK3MAPK1CYP2D6CYP2C9 | |
| SCHEMBL574873 | 0.76 | BRAF (0.42) | BRAFMAPK3MAPK1MAPK13CSNK1D | |
| SCHEMBL14108526 | 0.74 | BRAF (0.35) | BRAFMAPK3MAPK1ACVR1IRAK4 | |
| SCHEMBL28039527 | 0.73 | BRAF (0.34) | BRAFMAPK3MAPK1MAPK13CSNK1D | |
| SCHEMBL10216183 | 0.71 | BRAF (0.42) | BRAFMAPK3MAPK1MAPK13CSNK1D | |
| SCHEMBL14108524 | 0.70 | BRAF (0.35) | BRAFMAPK3MAPK1ACVR1 | |
| SCHEMBL15192043 | 0.67 | PIK3CA (0.43) | BRAF | |
| SCHEMBL2357717 | 0.67 | BRAF (0.34) | BRAFMAPK3MAPK1CYP2D6CYP2C9 | |
| SCHEMBL14108513 | 0.67 | PTGS2 (0.35) | BRAFMAPK3MAPK1MAPK13CSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103153980-B | Derivatives of pyrazolophenylbenzenesulfonamide compounds and their use as antitumor agents | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2015-12-16 | — | — | CN | disclosed |
| CN-103153980-A | Derivatives of pyrazolophenylbenzenesulfonamide compounds and their use as antitumor agents | NERVIANO MEDICAL SCIENCES SRL | 2013-06-12 | — | — | CN | disclosed |