SCHEMBL102234

SCHEMBL102234

OCc1nc(Br)cs1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1533682 0.78
SCHEMBL4008375 0.76
SCHEMBL1198255 0.76
SCHEMBL5233601 0.76
SCHEMBL19718384 0.73
SCHEMBL15110978 0.73
SCHEMBL23498353 0.71
SCHEMBL6233700 0.71
SCHEMBL475767 0.71
SCHEMBL8708380 0.71

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 237 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026103846-A1 CYCLIC COMPOUND AND PREPARATION THEREFOR AND PHARMACEUTICAL USE THEREOF 山东先声再明生物制药有限公司 2026-05-21 WO disclosed
EP-4558507-B1 MACROCYCLE COMPOUNDS FOR THE TREATMENT OF CANCER HOFFMANN LA ROCHE (CH) 2026-04-29 EP disclosed
WO-2026041636-A1 MACROCYCLE COMPOUNDS FOR THE TREATMENT OF CANCER F. HOFFMANN-LA ROCHE AG (CH) 2026-02-26 WO disclosed
EP-4688791-A1 TRICYCLIC COMPOUNDS FOR THE TREATMENT OF CANCER F. Hoffmann-La Roche AG (CH) 2026-02-11 EP disclosed
US-12545689-B2 Macrocyclic LRRK2 kinase inhibitors ONCODESIGN PRECISION MEDICINE (FR) 2026-02-10 US disclosed
US-20250376482-A1 TRICYCLIC COMPOUNDS FOR THE TREATMENT OF CANCER HOFFMANN-LA ROCHE INC. (US) 2025-12-11 US disclosed
EP-4649081-A1 SULFONYLVINYL COMPOUNDS FOR THE TREATMENT OF CANCER F. Hoffmann-La Roche AG (CH) 2025-11-19 EP disclosed
EP-4146658-B1 NEW MACROCYCLIC LRRK2 KINASE INHIBITORS ONCODESIGN PREC MEDICINE OPM (FR) 2025-10-29 EP disclosed
EP-4630424-A1 COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS Third Harmonic Bio, Inc. (US) 2025-10-15 EP disclosed
US-20250268894-A1 MACROCYCLE COMPOUNDS FOR THE TREATMENT OF CANCER HOFFMANN-LA ROCHE INC. (US) 2025-08-28 US disclosed
WO-2004046101-A2 CYANOGUANIDINES AND CYANOAMIDINES AS ERBB2 AND EGFR INHIBITORS ARRAY BIOPHARMA, INC. (US) 2004-06-03 WO disclosed
CN-1134444-C Epothilone analogs and pharmaceutical compositions thereof 普罗格特-甘布尔公司 2004-01-14 CN disclosed
US-6660758-B1 Prevention of mitosis; induction and stabilization of microtubules THE SCRIPPS RESEARCH INSTITUTE 2003-12-09 US disclosed
US-20030203938-A1 Epothilone derivatives and their synthesis and use THE SCRIPPS RESEARCH INSTITUTE 2003-10-30 US disclosed
US-6441186-B1 ANTICANCER AGENTS; PREVENTION OF MITOSIS THROUGH INDUCTION AND STABILIZATION OF MICROTUBULIN ASSEMBLY; SUPERIOR CYTOTOXIC ACTIVITIES THE SCRIPPS RESEARCH INSTITUTE 2002-08-27 US disclosed
EP-1089998-A2 EPOTHILONE DERIVATIVES AND THEIR SYNTHESIS AND USE Novartis AG (CH) 2001-04-11 EP disclosed
CN-1246862-A Epothilone analogs NOVARTIS AG (CH) 2000-03-08 CN disclosed
WO-1999067252-A2 EPOTHILONE DERIVATIVES AND THEIR SYNTHESIS AND USE NOVARTIS AG (CH) 1999-12-29 WO disclosed
EP-0944634-A1 EPOTHILONE ANALOGS Novartis AG (CH) 1999-09-29 EP disclosed
WO-1998025929-A1 EPOTHILONE ANALOGS NOVARTIS AG (CH) 1998-06-18 WO disclosed