SCHEMBL4008375

SCHEMBL4008375

CCc1nc(Br)cs1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1533682 0.78
SCHEMBL4700565 0.77 CNR2 (0.31)
SCHEMBL17374883 0.77 ECE1 (0.40)
SCHEMBL103565 0.76
SCHEMBL1198255 0.76
SCHEMBL102234 0.76
SCHEMBL5233601 0.76
SCHEMBL2724855 0.76
SCHEMBL12359888 0.76
Iodide SCHEMBL31511841 0.74

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230293522-A1 HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF SUMO ACTIVATING ENZYME TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2023-09-21 US disclosed
WO-2020023657-A1 PYRIDIN-2-ONE COMPOUNDS USEFUL AS SMARCA2 ANTAGONISTS Epizyme, Inc. (US) 2020-01-30 WO disclosed
US-20170216290-A1 HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF SUMO ACTIVATING ENZYME MILLENNIUM PHARMACEUTICALS, INC. (US) 2017-08-03 US disclosed
US-9683003-B2 Heteroaryl compounds useful as inhibitors of SUMO activating enzyme MILLENNIUM PHARMACEUTICALS, INC. (US) 2017-06-20 US disclosed
US-20170002032-A9 HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF SUMO ACTIVATING ENZYME MILLENNIUM PHARMACEUTICALS, INC. (US) 2017-01-05 US disclosed
US-20160009744-A1 HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF SUMO ACTIVATING ENZYME MILLENNIUM PHARMACEUTICALS, INC. (US) 2016-01-14 US disclosed
WO-2015154169-A1 BINDING FUNCTION3 (BF3) SITE COMPOUNDS AS THERAPEUTICS AND METHODS FOR THEIR USE THE UNIVERSITY OF BRITISH COLUMBIA (CA) 2015-10-15 WO disclosed
US-7579366-B2 Epothilone derivatives and their synthesis and use THE SCRIPPS RESEARCH INSTITUTE (US) 2009-08-25 US disclosed
US-7579366-B2 Epothilone derivatives and their synthesis and use THE SCRIPPS RESEARCH INSTITUTE (US) 2009-08-25 US disclosed
US-7173137-B2 Epothilone analogs THE SCRIPPS RESEARCH INSTITUTE (US) 2007-02-06 US disclosed
US-20030203938-A1 Epothilone derivatives and their synthesis and use THE SCRIPPS RESEARCH INSTITUTE 2003-10-30 US disclosed
US-6531497-B1 Proliferative diseases THE SCRIPPS RESEARCH INSTITUTE 2003-03-11 US disclosed
US-6441186-B1 ANTICANCER AGENTS; PREVENTION OF MITOSIS THROUGH INDUCTION AND STABILIZATION OF MICROTUBULIN ASSEMBLY; SUPERIOR CYTOTOXIC ACTIVITIES THE SCRIPPS RESEARCH INSTITUTE 2002-08-27 US disclosed
US-6380394-B1 ANTICANCER AGENTS THE SCRIPPS RESEARCH INSTITUTE 2002-04-30 US disclosed
CN-1306531-A Epsilon derivatives and their synthesis and use NOVARTIS AG (CH) 2001-08-01 CN disclosed
EP-1089998-A2 EPOTHILONE DERIVATIVES AND THEIR SYNTHESIS AND USE Novartis AG (CH) 2001-04-11 EP disclosed
CN-1246862-A Epothilone analogs NOVARTIS AG (CH) 2000-03-08 CN disclosed
WO-1999067252-A2 EPOTHILONE DERIVATIVES AND THEIR SYNTHESIS AND USE NOVARTIS AG (CH) 1999-12-29 WO disclosed
EP-0944634-A1 EPOTHILONE ANALOGS Novartis AG (CH) 1999-09-29 EP disclosed
WO-1998025929-A1 EPOTHILONE ANALOGS NOVARTIS AG (CH) 1998-06-18 WO disclosed