Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 12/20 | 0.66 |
| ▸ | EGFR | P00533 | 12/20 | 0.66 |
| ▸ | ABL1 | P00519 | 10/20 | 0.66 |
| ▸ | ABL2 | P42684 | 10/20 | 0.66 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.55 |
| ▸ | LCK | P06239 | 4/20 | 0.53 |
| ▸ | TEK | Q02763 | 3/20 | 0.53 |
| ▸ | KDR | P35968 | 3/20 | 0.53 |
| ▸ | LYN | P07948 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | RGS12 | O14924 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | GMNN | O75496 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | FYN | P06241 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL400053 | 0.88 | SRC (0.67) | SRCEGFRABL1ABL2RIPK2 | |
| SCHEMBL399677 | 0.83 | SRC (0.69) | SRCEGFRABL1ABL2RIPK2 | |
| SCHEMBL400308 | 0.81 | SRC (0.58) | SRCEGFRABL1ABL2RIPK2 | |
| SCHEMBL400839 | 0.81 | LCK (0.63) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL397857 | 0.80 | SRC (0.56) | SRCEGFRABL1ABL2RIPK2 | |
| SCHEMBL132510 | 0.80 | SRC (1.00) | SRCEGFRABL1ABL2RIPK2 | |
| SCHEMBL399476 | 0.77 | SRC (0.52) | SRCEGFRABL1ABL2RIPK2 | |
| SCHEMBL5936173 | 0.77 | SRC (0.97) | SRCEGFRABL1ABL2RIPK2 | |
| SCHEMBL400529 | 0.77 | EGFR (0.68) | SRCEGFRABL1ABL2RIPK2 | |
| SCHEMBL27658582 | 0.76 | SRC (0.69) | SRCEGFRABL1ABL2RIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8367826-B2 | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors | OSI Pharmaceuticals, LLC (US) | 2013-02-05 | — | — | US | disclosed |
| US-8367826-B2 | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors | OSI Pharmaceuticals, LLC (US) | 2013-02-05 | — | — | US | disclosed |
| US-20120077979-A1 | 6,6-Bicyclic Ring Substituted Heterobicyclic Protein Kinase Inhibitors | OSI Pharmaceuticals, LLC | 2012-03-29 | — | — | US | disclosed |
| US-20120077979-A1 | 6,6-Bicyclic Ring Substituted Heterobicyclic Protein Kinase Inhibitors | OSI Pharmaceuticals, LLC | 2012-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077979-A1 | 6,6-Bicyclic Ring Substituted Heterobicyclic Protein Kinase Inhibitors | IGF1R, MAP2K7, BRCA1 | SRC 299/4885EGFR 155/4885ABL1 621/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.