Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 13/20 | 0.97 |
| ▸ | EGFR | P00533 | 12/20 | 0.97 |
| ▸ | ABL1 | P00519 | 10/20 | 0.97 |
| ▸ | ABL2 | P42684 | 10/20 | 0.97 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.80 |
| ▸ | LCK | P06239 | 6/20 | 0.79 |
| ▸ | TEK | Q02763 | 5/20 | 0.79 |
| ▸ | KDR | P35968 | 4/20 | 0.79 |
| ▸ | LYN | P07948 | 2/20 | 0.79 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.79 |
| ▸ | MEN1 | O00255 | 1/20 | 0.79 |
| ▸ | RGS12 | O14924 | 1/20 | 0.79 |
| ▸ | NPC1 | O15118 | 1/20 | 0.79 |
| ▸ | GMNN | O75496 | 1/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.79 |
| ▸ | LMNA | P02545 | 1/20 | 0.79 |
| ▸ | TP53 | P04637 | 1/20 | 0.79 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.79 |
| ▸ | FYN | P06241 | 1/20 | 0.79 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL132510 | 0.96 | SRC (1.00) | SRCEGFRABL1ABL2RIPK2 | |
| SCHEMBL23834505 | 0.90 | SRC (0.98) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL29920993 | 0.88 | SRC (1.00) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL378454 | 0.88 | SRC (1.00) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL18044541 | 0.88 | SRC (0.81) | SRCEGFRABL1ABL2RIPK2 | |
| SCHEMBL23847632 | 0.88 | SRC (0.76) | SRCEGFRABL1ABL2RIPK2 | |
| SCHEMBL8320799 | 0.86 | SRC (0.81) | SRCEGFRABL1ABL2RIPK2 | |
| Hydrochloric Acid SCHEMBL7098308 | 0.86 | SRC (0.85) | SRCEGFRABL1ABL2RIPK2 | |
| SCHEMBL6870684 | 0.86 | SRC (0.77) | SRCEGFRABL1ABL2RIPK2 | |
| SCHEMBL6865396 | 0.86 | SRC (0.77) | SRCEGFRABL1ABL2RIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100413867-C | 4-amino-5-phenyl-7-cyclohexyl-pyrrolo[2,3-d]pyrimidine derivatives | NOVARTIS AG (CH) | 2008-08-27 | — | — | CN | disclosed |
| CN-100413867-C | 4-amino-5-phenyl-7-cyclohexyl-pyrrolo[2,3-d]pyrimidine derivatives | NOVARTIS AG (CH) | 2008-08-27 | — | — | CN | disclosed |
| CN-100413867-C | 4-amino-5-phenyl-7-cyclohexyl-pyrrolo[2,3-d]pyrimidine derivatives | NOVARTIS AG (CH) | 2008-08-27 | — | — | CN | disclosed |
| US-20060058324-A1 | 4-Amino-5-phenyl-7-cyclohexyl-pyrrolo 2,3-d pyrimidine derivatives | CAPRARO HANS-GEORG | 2006-03-16 | — | — | US | disclosed |
| US-20060058324-A1 | 4-Amino-5-phenyl-7-cyclohexyl-pyrrolo 2,3-d pyrimidine derivatives | CAPRARO HANS-GEORG | 2006-03-16 | — | — | US | disclosed |
| CN-1711269-A | 4-amino-5-phenyl-7-cyclohexyl-pyrrolo[2,3-d]pyrimidine derivatives | NOVARTIS AG (CH) | 2005-12-21 | — | — | CN | disclosed |
| CN-1711269-A | 4-amino-5-phenyl-7-cyclohexyl-pyrrolo[2,3-d]pyrimidine derivatives | NOVARTIS AG (CH) | 2005-12-21 | — | — | CN | disclosed |
| CN-1711269-A | 4-amino-5-phenyl-7-cyclohexyl-pyrrolo[2,3-d]pyrimidine derivatives | NOVARTIS AG (CH) | 2005-12-21 | — | — | CN | disclosed |
| EP-1562947-A1 | 4-AMINO-5-PHENYL-7-CYCLOHEXYL-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES | Novartis AG (CH) | 2005-08-17 | — | — | EP | disclosed |
| EP-1562947-A1 | 4-AMINO-5-PHENYL-7-CYCLOHEXYL-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES | Novartis AG (CH) | 2005-08-17 | — | — | EP | disclosed |
| US-6855710-B2 | Substituted indolines with an inhibitory effect on various kinases and complexes of CDKs | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2005-02-15 | — | — | US | disclosed |
| WO-2004043962-A1 | 4-AMINO-5-PHENYL-7-CYCLOHEXYL-PYRROLO[2,3-d]PYRIMIDINE DERIVATIVES | NOVARTIS AG (CH) | 2004-05-27 | — | — | WO | disclosed |
| WO-2004043962-A1 | 4-AMINO-5-PHENYL-7-CYCLOHEXYL-PYRROLO[2,3-d]PYRIMIDINE DERIVATIVES | NOVARTIS AG (CH) | 2004-05-27 | — | — | WO | disclosed |
| WO-2004043962-A1 | 4-AMINO-5-PHENYL-7-CYCLOHEXYL-PYRROLO[2,3-d]PYRIMIDINE DERIVATIVES | NOVARTIS AG (CH) | 2004-05-27 | — | — | WO | disclosed |
| US-20040058978-A1 | Novel substituted indolines with an inhibitory effect on various kinases and complexes of CDKs | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2004-03-25 | — | — | US | disclosed |
| WO-1997028161-A1 | NOVEL PYRROLO[2,3-D]PYRIMIDINES AND THEIR USE AS TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 1997-08-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060058324-A1 | 4-Amino-5-phenyl-7-cyclohexyl-pyrrolo 2,3-d pyrimidine derivatives | TYMP, TYMS, APRT | SRC 2628/4885EGFR 2263/4885ABL1 1254/4885 |
| US-20040058978-A1 | Novel substituted indolines with an inhibitory effect on various kinases and complexes of CDKs | CDK1, CDK2, CDK3 | SRC 140/4885EGFR 152/4885ABL1 68/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.