Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 3/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.49 |
| ▸ | RET | P07949 | 2/20 | 0.49 |
| ▸ | BCR | P11274 | 1/20 | 0.49 |
| ▸ | FRK | P42685 | 1/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.49 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.49 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.49 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.49 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.49 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.49 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.49 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.49 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.49 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 11/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.35 |
| ▸ | BRAF | P15056 | 6/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10273340 | 0.92 | RET (0.49) | FLT3FGFR1RETBCRFRK | |
| SCHEMBL15435525 | 0.87 | FGFR1 (0.64) | FLT3FGFR1RETBCRFRK | |
| SCHEMBL276467 | 0.82 | FGFR1 (0.66) | FLT3FGFR1RETBCRFRK | |
| SCHEMBL10225846 | 0.80 | FGFR1 (0.49) | FLT3FGFR1RETBCRFRK | |
| SCHEMBL9979888 | 0.79 | FGFR1 (0.63) | FLT3FGFR1RETBCRFRK | |
| SCHEMBL5182413 | 0.78 | RET (0.56) | FLT3FGFR1RETBCRFRK | |
| SCHEMBL276552 | 0.78 | FGFR1 (0.67) | FLT3FGFR1RETBCRFRK | |
| SCHEMBL276616 | 0.76 | FGFR1 (0.69) | FLT3FGFR1RETBCRFRK | |
| SCHEMBL279530 | 0.75 | FGFR1 (0.61) | FLT3FGFR1RETBCRFRK | |
| SCHEMBL276273 | 0.74 | FGFR1 (0.69) | FLT3FGFR1RETBCRFRK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165314-A1 | SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | BAYER HEALTHCARE LLC (US) | 2012-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165314-A1 | SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | CDK4, FLT4, CDKL4 | FLT3 318/4885FGFR1 19/4885RET 1216/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.