Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 4/20 | 0.64 |
| ▸ | FLT3 | P36888 | 4/20 | 0.64 |
| ▸ | RET | P07949 | 3/20 | 0.64 |
| ▸ | FRK | P42685 | 3/20 | 0.64 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.64 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.64 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.64 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.64 |
| ▸ | BCR | P11274 | 1/20 | 0.64 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.64 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.64 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.64 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.64 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.64 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.64 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.41 |
| ▸ | KDR | P35968 | 11/20 | 0.37 |
| ▸ | FLT1 | P17948 | 6/20 | 0.37 |
| ▸ | TEK | Q02763 | 4/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL276467 | 0.94 | FGFR1 (0.66) | FGFR1FLT3RETFRKMAPK9 | |
| SCHEMBL9979888 | 0.92 | FGFR1 (0.63) | FGFR1FLT3RETFRKMAPK9 | |
| SCHEMBL276552 | 0.90 | FGFR1 (0.67) | FGFR1FLT3RETFRKMAPK9 | |
| SCHEMBL276616 | 0.89 | FGFR1 (0.69) | FGFR1FLT3RETFRKMAPK9 | |
| SCHEMBL10225844 | 0.87 | FLT3 (0.49) | FGFR1FLT3RETFRKMAPK9 | |
| SCHEMBL5182413 | 0.87 | RET (0.56) | FGFR1FLT3RETFRKMAPK9 | |
| SCHEMBL276273 | 0.87 | FGFR1 (0.69) | FGFR1FLT3RETFRKMAPK9 | |
| SCHEMBL279530 | 0.86 | FGFR1 (0.61) | FGFR1FLT3RETFRKMAPK9 | |
| SCHEMBL327903 | 0.82 | FGFR1 (0.60) | FGFR1FLT3RETFRKMAPK9 | |
| SCHEMBL276489 | 0.81 | FGFR1 (0.73) | FGFR1FLT3RETFRKMAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8829185-B2 | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis | BAYER HEALTHCARE LLC (US) | 2014-09-09 | — | — | US | disclosed |
| US-8829185-B2 | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis | BAYER HEALTHCARE LLC (US) | 2014-09-09 | — | — | US | disclosed |
| EP-1957077-B1 | SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | BAYER HEALTHCARE LLC (US) | 2014-01-22 | — | — | EP | disclosed |