Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7683450 | 0.84 | CNR2 (0.47) | HPGDCYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL8312174 | 0.83 | TRPV1 (0.44) | HPGDCYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL7675508 | 0.81 | TRPV1 (0.50) | TRPV1CNR2HDAC1SMN1; SMN2SCN9A | |
| SCHEMBL17116613 | 0.80 | CNR2 (0.51) | HPGDTRPV1CNR2HDAC1ALDH1A1 | |
| SCHEMBL1146096 | 0.79 | HDAC1 (0.51) | HPGDTRPV1CNR2HDAC1ALDH1A1 | |
| SCHEMBL29768457 | 0.79 | HDAC1 (0.51) | HPGDTRPV1CNR2HDAC1ALDH1A1 | |
| SCHEMBL24185307 | 0.78 | CNR2 (0.50) | HPGDTRPV1CNR2HDAC1ALDH1A1 | |
| SCHEMBL18461458 | 0.78 | HDAC1 (0.51) | HPGDTRPV1CNR2HDAC1ALDH1A1 | |
| SCHEMBL21283226 | 0.78 | CNR2 (0.50) | CYP1A2CYP2C9CYP2C19CYP3A4TRPV1 | |
| SCHEMBL2471399 | 0.78 | ESR2 (0.53) | HPGDTRPV1CNR2HDAC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8114893-B2 | Compounds and methods of use | GENENTECH, INC. (US) | 2012-02-14 | — | — | US | disclosed |