Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NAAA | Q02083 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10227481 | 0.83 | HPGD (0.58) | TRPV1CNR2HDAC1HPGDCYP1A2 | |
| SCHEMBL16879478 | 0.80 | ALDH1A1 (0.59) | TRPV1CNR2HDAC1HPGDNPC1 | |
| SCHEMBL7683450 | 0.80 | CNR2 (0.47) | TRPV1CNR2HDAC1HPGDCYP1A2 | |
| SCHEMBL2471399 | 0.78 | ESR2 (0.53) | TRPV1CNR2HDAC1HPGDALDH1A1 | |
| SCHEMBL7675508 | 0.78 | TRPV1 (0.50) | TRPV1CNR2HDAC1SMN1; SMN2KCNH2 | |
| SCHEMBL17116613 | 0.76 | CNR2 (0.51) | TRPV1CNR2HDAC1HPGDALDH1A1 | |
| SCHEMBL29768457 | 0.76 | HDAC1 (0.51) | TRPV1CNR2HDAC1HPGDALDH1A1 | |
| SCHEMBL1146096 | 0.76 | HDAC1 (0.51) | TRPV1CNR2HDAC1HPGDALDH1A1 | |
| SCHEMBL6953214 | 0.75 | ESR2 (0.59) | CNR2NAAA | |
| SCHEMBL24185307 | 0.74 | CNR2 (0.50) | TRPV1CNR2HDAC1HPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0628046-B1 | TRIAZOLOPYRIMIDIN DERIVATIVES AS ANTIOTENSIN II RECEPTOR ANTAGONISTS | UNION PHARMA SCIENT APPL (FR) | 1999-05-12 | — | — | EP | disclosed |
| US-5389632-A | Cardiovascular disorders | LABORATOIRES UPSA (FR) | 1995-02-14 | — | — | US | disclosed |
| US-5387747-A | Used in the treatment and prevention of cardiovascular diseases: hypertension, cardiac insufficiency and atherosclerosis | LABORATOIRES UPSA (FR) | 1995-02-07 | — | — | US | disclosed |
| EP-0628046-A1 | TRIAZOLOPYRIMIDIN DERIVATIVES AS ANTIOTENSIN II RECEPTOR ANTAGONISTS | LABORATOIRES UPSA (FR) | 1994-12-14 | — | — | EP | disclosed |
| EP-0628045-A1 | PYRAZOLOPYRIMIDIN DERIVATIVES AS ANGIOTENSIN II RECEPTOR ANTAGONISTS | LABORATOIRES UPSA (FR) | 1994-12-14 | — | — | EP | disclosed |
| WO-1993017023-A1 | PYRAZOLOPYRIMIDIN DERIVATIVES AS ANGIOTENSIN II RECEPTOR ANTAGONISTS | LABORATOIRES UPSA (FR) | 1993-09-02 | — | — | WO | disclosed |
| WO-1993017024-A1 | TRIAZOLOPYRIMIDIN DERIVATIVES AS ANTIOTENSIN II RECEPTOR ANTAGONISTS | LABORATOIRES UPSA (FR) | 1993-09-02 | — | — | WO | disclosed |