Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 12/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | HBB | P68871 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1720425 | 0.88 | PARP1 (0.54) | PARP1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL1721096 | 0.80 | PARP1 (0.43) | PARP1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL1719564 | 0.76 | HTR6 (0.56) | PARP1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL1721180 | 0.76 | PARP1 (0.61) | PARP1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL1720655 | 0.75 | MCL1 (0.41) | PARP1ALDH1A1 | |
| SCHEMBL10227704 | 0.74 | PARP1 (0.43) | PARP1KDM4E | |
| SCHEMBL1720570 | 0.73 | CYP19A1 (0.42) | PARP1KDM4EALDH1A1POLB | |
| SCHEMBL1720059 | 0.73 | CYP19A1 (0.42) | PARP1KDM4EALDH1A1POLB | |
| SCHEMBL1720056 | 0.73 | CYP19A1 (0.42) | PARP1KDM4EALDH1A1POLB | |
| SCHEMBL2564576 | 0.72 | HTR6 (0.53) | PARP1MEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1566380-B1 | ISOQUINOLINE COMPOUNDS AND MEDICINAL USE THEREOF | MITSUBISHI TANABE PHARMA CORP (JP) | 2012-01-11 | — | — | EP | disclosed |