Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 4/20 | 0.39 |
| ▸ | CTSL | P07711 | 2/20 | 0.39 |
| ▸ | CTSB | P07858 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CTSK | P43235 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4853174 | 0.85 | SYK (0.56) | SYKATMMAPT | |
| SCHEMBL4850221 | 0.85 | SYK (0.49) | SYKMMP1MMP3MMP9ATM | |
| SCHEMBL4850228 | 0.85 | SYK (0.49) | SYKMMP1MMP3MMP9ATM | |
| SCHEMBL4852088 | 0.83 | SYK (0.48) | SYKMMP1MMP3MMP9ATM | |
| SCHEMBL1024156 | 0.83 | SYK (0.48) | SYKMMP1MMP3MMP9ATM | |
| SCHEMBL1023983 | 0.82 | SYK (0.42) | SYKMMP1MMP3MMP9ATM | |
| SCHEMBL4847719 | 0.81 | SYK (0.47) | SYKMMP1MMP3MMP9ATM | |
| SCHEMBL4847703 | 0.81 | SYK (0.47) | SYKMMP1MMP3MMP9ATM | |
| SCHEMBL1024124 | 0.81 | CTSS (0.49) | SYKMMP1MMP3MMP9ATM | |
| SCHEMBL4848456 | 0.81 | CTSS (0.49) | SYKMMP1MMP3MMP9ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797110-B1 | ANTIBACTERIAL AMIDE MACROCYCLES IV | AICURIS GMBH & CO KG (DE) | 2011-01-12 | — | — | EP | disclosed |