Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 17/20 | 0.72 |
| ▸ | LCK | P06239 | 3/20 | 0.57 |
| ▸ | HTR2C | P28335 | 1/20 | 0.56 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.55 |
| ▸ | AKT2 | P31751 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20470386 | 0.95 | JAK3 (0.69) | JAK3LCKHTR2CDOT1LAKT2 | |
| SCHEMBL2018963 | 0.85 | JAK3 (1.00) | JAK3LCKHTR2CDOT1LAKT2 | |
| SCHEMBL3959075 | 0.85 | JAK3 (1.00) | JAK3LCKHTR2CDOT1LAKT2 | |
| SCHEMBL1048998 | 0.85 | JAK3 (1.00) | JAK3LCKHTR2CDOT1LAKT2 | |
| SCHEMBL1818852 | 0.83 | JAK3 (1.00) | JAK3LCKHTR2CDOT1LAKT2 | |
| SCHEMBL323332 | 0.81 | HTR2C (0.69) | JAK3LCKHTR2CDOT1LAKT2 | |
| SCHEMBL10206799 | 0.81 | JAK3 (0.83) | JAK3LCKHTR2CDOT1L | |
| SCHEMBL2021631 | 0.81 | JAK3 (0.68) | JAK3LCK | |
| SCHEMBL31550436 | 0.80 | JAK3 (0.93) | JAK3LCKHTR2CDOT1LAKT2 | |
| SCHEMBL29073290 | 0.80 | AKT2 (0.68) | JAK3LCKHTR2CDOT1LAKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012003829-A1 | NOVEL HOMOPIPERAZINE DERIVATIVES AS PROTEIN TYROSINE KINASE INHIBITORS AND PHARMACEUTICAL USE THEREOF | LEO PHARMA A/S (DK) | 2012-01-12 | — | — | WO | disclosed |