Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.85 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.83 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.77 |
| ▸ | MAPT | P10636 | 7/20 | 0.73 |
| ▸ | THRB | P10828 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1073720 | 0.92 | TP53 (0.86) | TP53SMN1; SMN2RXFP1MAPTTHRB | |
| SCHEMBL1075310 | 0.91 | TP53 (0.85) | TP53SMN1; SMN2RXFP1MAPTTHRB | |
| SCHEMBL1070384 | 0.91 | SMN1; SMN2 (1.00) | TP53SMN1; SMN2RXFP1MAPTTHRB | |
| SCHEMBL1021628 | 0.91 | SMN1; SMN2 (1.00) | TP53SMN1; SMN2RXFP1MAPTTHRB | |
| SCHEMBL1074878 | 0.90 | TP53 (0.82) | TP53SMN1; SMN2RXFP1MAPTTHRB | |
| SCHEMBL1022855 | 0.89 | TP53 (0.81) | TP53SMN1; SMN2RXFP1MAPTTHRB | |
| SCHEMBL1021443 | 0.88 | RXFP1 (0.80) | TP53SMN1; SMN2RXFP1MAPTPOLB | |
| SCHEMBL1075018 | 0.88 | RXFP1 (0.88) | TP53SMN1; SMN2RXFP1MAPTTHRB | |
| SCHEMBL15411288 | 0.88 | MAPT (0.67) | TP53SMN1; SMN2RXFP1MAPTPOLB | |
| SCHEMBL1074208 | 0.87 | RXFP1 (1.00) | TP53SMN1; SMN2RXFP1MAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2314590-A1 | Substituted quinolones and methods of use | ChemoCentryx, Inc. (US) | 2011-04-27 | — | — | EP | disclosed |
| EP-1954274-B8 | SUBSTITUTED QUINOLONES AND METHODS OF USE | CHEMOCENTRYX INC (US) | 2011-01-12 | — | — | EP | disclosed |
| EP-1954274-B1 | SUBSTITUTED QUINOLONES AND METHODS OF USE | CHEMOCENTRYX INC (US) | 2010-11-03 | — | — | EP | disclosed |
| US-7557213-B2 | Substituted quinolones and methods of use | CHEMOCENTRYX, INC. (US) | 2009-07-07 | — | — | US | disclosed |
| EP-1954274-A4 | SUBSTITUTED QUINOLONES AND METHODS OF USE | CHEMOCENTRYX INC (US) | 2009-01-07 | — | — | EP | disclosed |
| EP-1954274-A2 | SUBSTITUTED QUINOLONES AND METHODS OF USE | ChemoCentryx Inc (US) | 2008-08-13 | — | — | EP | disclosed |
| US-20070167443-A1 | Substituted quinolones and methods of use | CHEMOCENTRYX, INC. (US) | 2007-07-19 | — | — | US | disclosed |
| WO-2007059108-A2 | SUBSTITUTED QUINOLONES AND METHODS OF USE | CHEMOCENTRYX, INC. (US) | 2007-05-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070167443-A1 | Substituted quinolones and methods of use | TOP2A, NQO2, TOP2B | TP53 40/4885SMN1; SMN2 2712/4885RXFP1 4610/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.