TOP2B

DNA topoisomerase 2-beta · Q02880 · TOP2B on Sugi Atlas →

40,646 patent compounds predicted against TOP2B, 27,557 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL496905	0.58	13/20
Delafloxacin (SCHEMBL294694)	0.40	10/20
Delafloxacin (SCHEMBL441203)	0.40	10/20
Tosufloxacin (SCHEMBL34354)	0.52	9/20
Tosufloxacin (SCHEMBL34355)	0.52	9/20
SCHEMBL500455	0.53	8/20
Purpurin (SCHEMBL33871)	0.53	8/20
Ibafloxacin (SCHEMBL154637)	0.51	8/20
SCHEMBL500719	0.71	7/20
SCHEMBL500386	0.64	7/20
SCHEMBL143295	0.60	7/20
Clinafloxacin (SCHEMBL33959)	0.56	7/20
Clinafloxacin (SCHEMBL33960)	0.56	7/20
Clinafloxacin (SCHEMBL193233)	0.55	7/20
Clinafloxacin (SCHEMBL193234)	0.55	7/20
SCHEMBL500472	0.53	7/20
SCHEMBL116806	0.52	7/20
SCHEMBL143404	0.52	7/20
SCHEMBL116358	0.51	7/20
SCHEMBL116006	0.50	7/20

Clinical trials — most relevant to TOP2B by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Venetoclax+HMA+Aclarubicin Versus Venetoclax+HMA in Treatment-Naive Elderly Patients With AML	PHASE3	UNKNOWN
Lipiodol-TACE With Idarubicin for Hepatocellular Carcinoma	PHASE2/PHASE3	UNKNOWN
A Study of Children With Refractory or Relapsed ALL	PHASE3	COMPLETED
Study of Carfilzomib With Irinotecan in Irinotecan-Sensitive Malignancies and Small Cell Lung Cancer Patients	PHASE1/PHASE2	COMPLETED
Clinical and Pharmacological Study With 2B3-101 in Patients With Breast Cancer and Leptomeningeal Metastases	PHASE2	UNKNOWN
Biologic Correlative Taxotere/AC	PHASE2	COMPLETED
How To Evaluate The Efficiency And Safety Of Neoadjuvant Chemotherapy In Locally Advanced Cancer Cervix	PHASE2	UNKNOWN
Combination Chemotherapy Followed by Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Non-Hodgkin's Lymphoma or Hodgkin's Lymphoma	PHASE2	COMPLETED
Phase II Trial With Correlative Laboratory Studies of Single Agent Irinotecan (Camptosar CPT-11)	PHASE2	COMPLETED
PLX038 (PEGylated SN38) and Rucaparib in Solid Tumors and Small Cell Cancers	PHASE1/PHASE2	COMPLETED
Cyclophosphamide and Docetaxel or Doxorubicin in Treating Women With Newly Diagnosed Breast Cancer That Can Be Removed by Surgery	PHASE2	UNKNOWN
Topotecan for Irinotecan-Refractory SCLC	PHASE2	UNKNOWN
Efficacy and Safety Study of Sorafenib With Topotecan in Patients With Platinum-resistant Recurrent Ovarian Cancer	PHASE2	COMPLETED
Trial of Topotecan With VX-970 (M6620), an ATR Kinase Inhibitor, in Small Cell Cancers and Extrapulmonary Small Cell Cancers	PHASE1/PHASE2	COMPLETED
Study of AR-67 (DB-67) in Myelodysplastic Syndrome (MDS)	PHASE2	UNKNOWN
Indenoisoquinoline LMP744 in Adults With Relapsed Solid Tumors and Lymphomas	PHASE1	COMPLETED
A Phase I Study of Indenoisoquinolines LMP400 and LMP776 in Adults With Relapsed Solid Tumors and Lymphomas	PHASE1	COMPLETED
Topotecan Hydrochloride and Doxorubicin Hydrochloride in Treating Relapsed or Refractory Small Cell Lung Cancer	PHASE1	COMPLETED
Testing the Addition of an Anti-cancer Drug, BAY 1895344, to Usual Chemotherapy for Advanced Stage Solid Tumors, With a Specific Focus on Patients With Small Cell Lung Cancer, Poorly Differentiated Neuroendocrine Cancer, and Pancreatic Cancer	PHASE1	ACTIVE_NOT_RECRUITING
Indenoisoquinoline LMP400 for Advanced Solid Tumors and Lymphomas	PHASE1	COMPLETED
Safety Study of ABT-888 Plus Topotecan Hydrochloride to Treat Patients With Solid Tumors and Lymphomas	PHASE1	COMPLETED
Clinical Benefit of Topoisomerase Downregulation	PHASE1	COMPLETED
Vorinostat and Doxorubicin in Treating Patients With Metastatic or Locally Advanced Solid Tumors	PHASE1	COMPLETED
Azacitidine, Cytarabine, and Mitoxantrone Hydrochloride in Treating Patients With High-Risk Acute Myeloid Leukemia	PHASE1	COMPLETED
Tabectedin to Treat Children and Adolescents With Cancer	PHASE1	COMPLETED
Doxil Topotecan Doublet Cancer Study	PHASE1	COMPLETED
A Pilot Study of Parenteral Testosterone and Oral Etoposide as Therapy for Men With Castration Resistant Prostate Cancer	nan	COMPLETED
Biomarkers in Tumor Tissue Samples From Patients With Stage III, Stage IV, or Recurrent Endometrial Cancer	nan	COMPLETED
Plant Extracted Natural Compounds Impact on Stage IV Breast Cancer Survival Time and Remission.	nan	UNKNOWN
Lipiodol-TACE With Idarubicin Based On a Specific Emulsion Ratio for Hepatocellular Carcinoma	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a TOP2B binder may also engage these)

Protein	Name	Similarity
Q64511	—	1.000	Q64511 →
O42131	—	1.000	O42131 →
Q64399	—	1.000	Q64399 →
O46374	—	1.000	O46374 →
O42130	—	1.000	O42130 →
Q23670	—	1.000	Q23670 →
TOP2A	DNA topoisomerase 2-alpha	1.000	landscape →
Q01320	—	1.000	Q01320 →
P41515	—	1.000	P41515 →
P41516	—	1.000	P41516 →
P15348	—	1.000	P15348 →
O16140	—	1.000	O16140 →
P08096	—	0.996	P08096 →
P06786	—	0.996	P06786 →
P87078	—	0.995	P87078 →
O24308	—	0.995	O24308 →
Q01879	—	0.995	Q01879 →
O93794	—	0.994	O93794 →
P30182	—	0.994	P30182 →
Q9Y8G8	—	0.993	Q9Y8G8 →
G5ECQ8	—	0.992	G5ECQ8 →
O87545	—	0.990	O87545 →
NAT10	RNA cytidine acetyltransferase	0.990	landscape →
Q55BP5	—	0.989	Q55BP5 →
Q9W3C1	—	0.988	Q9W3C1 →
P53914	—	0.988	P53914 →
P94604	—	0.987	P94604 →
Q9L7L3	—	0.987	Q9L7L3 →
Q9A0L0	—	0.987	Q9A0L0 →
Q9LTR9	—	0.987	Q9LTR9 →