Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 11/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 11/20 | 0.43 |
| ▸ | DRD2 | P14416 | 10/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13823162 | 0.86 | KCNH2 (0.49) | DRD3KCNH2DRD2 | |
| SCHEMBL10237772 | 0.86 | DRD2 (0.49) | DRD3KCNH2DRD2 | |
| SCHEMBL14606195 | 0.85 | DRD2 (0.53) | DRD3KCNH2DRD2 | |
| SCHEMBL11459955 | 0.85 | DRD3 (0.42) | DRD3KCNH2DRD2 | |
| SCHEMBL4074941 | 0.84 | KCNH2 (0.43) | DRD3KCNH2DRD2 | |
| Hydrochloric Acid SCHEMBL11478772 | 0.84 | DRD3 (0.42) | DRD3KCNH2DRD2 | |
| Hydrochloric Acid SCHEMBL5447866 | 0.83 | KCNH2 (0.42) | DRD3KCNH2DRD2 | |
| SCHEMBL14606013 | 0.83 | DRD3 (0.55) | DRD3KCNH2DRD2 | |
| SCHEMBL6002385 | 0.81 | KCNH2 (0.52) | DRD3KCNH2DRD2 | |
| SCHEMBL4075128 | 0.81 | KCNH2 (0.52) | DRD3KCNH2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2060570-B1 | Azabicyclo[3.1.0] hexane derivatives useful as modulators of dopamine D3 receptors | GLAXO GROUP LTD (GB) | 2012-01-25 | — | — | EP | disclosed |
| EP-2070922-A1 | Azabicyclo(3.1.0) hexane derivatives useful as modulators of dopamine D3 receptors | GLAXO GROUP LIMITED (GB) | 2009-06-17 | — | — | EP | disclosed |
| EP-2060570-A2 | Azabicyclo(3.1.0) hexane derivatives useful as modulators of dopamine D3 receptors | Glaxo Group Limited (GB) | 2009-05-20 | — | — | EP | disclosed |