Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ATM | Q13315 | 2/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | DUT | P33316 | 1/20 | 0.32 |
| ▸ | STK17B | O94768 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8515935 | 0.88 | KDM4E (0.34) | KDM4EDUTSTK17B | |
| SCHEMBL8515932 | 0.88 | KDM4E (0.34) | KDM4EDUTSTK17B | |
| SCHEMBL8515929 | 0.88 | KDM4E (0.34) | KDM4EDUTSTK17B | |
| SCHEMBL10237755 | 0.82 | ATM (0.33) | KDM4EATMRAD52DUT | |
| SCHEMBL10237757 | 0.75 | AKT1 (0.47) | KDM4EATMRAD52DUT | |
| SCHEMBL874944 | 0.71 | DUT (0.32) | DUT | |
| SCHEMBL874288 | 0.71 | PPIB (0.33) | KDM4EDUTSTK17B | |
| SCHEMBL873832 | 0.64 | AKT1 (0.49) | KDM4EATMRAD52DUT | |
| SCHEMBL891554 | 0.63 | DUT (0.32) | DUT | |
| SCHEMBL10237756 | 0.63 | KDM4E (0.38) | KDM4EATMRAD52STK17B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120157448-A1 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | GENENTECH, INC. | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157448-A1 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | BACE1, PSEN1, PSEN2 | KDM4E 3940/4885ATM 3827/4885RAD52 4507/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.