Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 14/20 | 0.58 |
| ▸ | IRAK4 | Q9NWZ3 | 9/20 | 0.58 |
| ▸ | IRAK1 | P51617 | 3/20 | 0.58 |
| ▸ | LCK | P06239 | 2/20 | 0.58 |
| ▸ | RET | P07949 | 2/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.58 |
| ▸ | CDK7 | P50613 | 2/20 | 0.58 |
| ▸ | BLK | P51451 | 2/20 | 0.58 |
| ▸ | CCNH | P51946 | 2/20 | 0.58 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.58 |
| ▸ | NRAS | P01111 | 7/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL376983 | 0.94 | FLT3 (0.57) | FLT3IRAK4IRAK1LCKRET | |
| SCHEMBL376738 | 0.85 | FLT3 (0.79) | FLT3IRAK4IRAK1LCKRET | |
| SCHEMBL10239509 | 0.85 | FLT3 (0.61) | FLT3IRAK4IRAK1LCKRET | |
| SCHEMBL10239817 | 0.85 | FLT3 (0.61) | FLT3IRAK4IRAK1LCKRET | |
| SCHEMBL10239892 | 0.85 | FLT3 (0.57) | FLT3IRAK4IRAK1LCKRET | |
| SCHEMBL376565 | 0.85 | FLT3 (0.58) | FLT3IRAK4IRAK1LCKRET | |
| SCHEMBL376740 | 0.85 | IRAK4 (0.64) | FLT3IRAK4IRAK1LCKRET | |
| SCHEMBL10239097 | 0.83 | FLT3 (0.58) | FLT3IRAK4IRAK1LCKRET | |
| SCHEMBL10239502 | 0.82 | FLT3 (0.57) | FLT3IRAK4IRAK1LCKRET | |
| SCHEMBL31000238 | 0.82 | IRAK4 (0.54) | FLT3IRAK4IRAK1LCKRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2328890-B1 | 6 SUBSTITUTED 2-HETEROCYCLYLAMINO PYRAZINE COMPOUNDS AS CHK-1 INHIBITORS | PFIZER (US) | 2012-01-25 | — | — | EP | disclosed |
| WO-2010016005-A1 | 6 SUBSTITUTED 2-HETEROCYCLYLAMINO PYRAZINE COMPOUNDS AS CHK-1 INHIBITORS | PFIZER INC. (US) | 2010-02-11 | — | — | WO | disclosed |