Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DEGS1 | O15121 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10239628 | 0.85 | NPC1 (0.45) | DEGS1NPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL10239327 | 0.85 | NPC1 (0.45) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL10238343 | 0.82 | ADORA2A (0.46) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL10238923 | 0.80 | ABL1 (0.48) | DEGS1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL10151385 | 0.77 | NPC1 (0.36) | NPC1RAB9ASMN1; SMN2KMT2AMAPT | |
| SCHEMBL2093770 | 0.77 | F10 (0.45) | DEGS1NPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL2093370 | 0.77 | DEGS1 (0.45) | DEGS1NPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL2095105 | 0.77 | MEN1 (0.48) | DEGS1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL2094250 | 0.76 | DEGS1 (0.45) | DEGS1NPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL2093208 | 0.76 | DEGS1 (0.44) | DEGS1NPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163777-B2 | Benzimidazolyl-pyridine compounds for inflammation and immune-related uses | SYNTA PHARMACEUTICALS CORP. (US) | 2012-04-24 | — | — | US | disclosed |