Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | F10 | P00742 | 2/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10151390 | 0.82 | RAB9A (0.42) | NPC1RAB9ATP53MITFGAA | |
| SCHEMBL645754 | 0.79 | HPGDS (0.40) | NPC1RAB9ATP53F10MITF | |
| SCHEMBL10239334 | 0.77 | DEGS1 (0.43) | NPC1RAB9ATP53HPGDSKMT2A | |
| SCHEMBL647011 | 0.77 | GRM5 (0.39) | NPC1RAB9ATP53F10MITF | |
| SCHEMBL10151672 | 0.77 | RAB9A (0.44) | NPC1RAB9AKMT2AGRM5KDM4E | |
| SCHEMBL10151674 | 0.76 | TP53 (0.38) | NPC1RAB9ATP53MITFGAA | |
| SCHEMBL648228 | 0.76 | F10 (0.43) | NPC1RAB9ATP53F10MITF | |
| SCHEMBL645944 | 0.75 | NPC1 (0.37) | NPC1RAB9ATP53F10MITF | |
| SCHEMBL645920 | 0.75 | ORAI1 (0.45) | NPC1RAB9ATP53MITFGAA | |
| SCHEMBL646333 | 0.74 | NPC1 (0.46) | NPC1RAB9ATP53GAABRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119643-B2 | Benzoimidazolyl-pyrazine compounds for inflammation and immune-related uses | SYNTA PHARMACEUTICALS CORP. (US) | 2012-02-21 | — | — | US | disclosed |