Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 8/20 | 0.60 |
| ▸ | IDO1 | P14902 | 2/20 | 0.56 |
| ▸ | KCNMA1 | Q12791 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14354719 | 0.86 | GAA (0.72) | GAAKCNMA1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL14354746 | 0.83 | GAA (0.60) | GAAKCNMA1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL12339799 | 0.82 | GAA (0.58) | GAAKCNMA1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL12339796 | 0.82 | GAA (0.58) | GAAKCNMA1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL14354724 | 0.82 | GAA (0.58) | GAAKCNMA1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL12125130 | 0.81 | GAA (0.57) | GAAKCNMA1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL4971171 | 0.81 | GAA (0.57) | GAAKCNMA1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL10239297 | 0.81 | IDO1 (0.54) | GAAIDO1KCNMA1SMN1; SMN2CA12 | |
| SCHEMBL14354732 | 0.80 | GAA (0.56) | GAAKCNMA1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL12432821 | 0.80 | GAA (0.56) | GAAKCNMA1SMN1; SMN2MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8501804-B2 | Bicyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-08-06 | — | — | US | disclosed |
| US-20120010247-A1 | BICYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010247-A1 | BICYCLIC COMPOUND | ACACA, CPT1B, ACACB | GAA 1084/4885IDO1 3201/4885KCNMA1 2260/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.