ACACA — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL256483	0.74	15/20
SCHEMBL143382	0.70	13/20
SCHEMBL143383	0.70	13/20
SCHEMBL255802	0.56	13/20
SCHEMBL249181	0.53	13/20
SCHEMBL600251	0.49	13/20
SCHEMBL256524	0.63	12/20
SCHEMBL248033	0.55	12/20
SCHEMBL358893	0.51	12/20
SCHEMBL290583	0.51	12/20
SCHEMBL31526	0.46	12/20
SCHEMBL255780	0.60	11/20
SCHEMBL256484	0.52	11/20
SCHEMBL358674	0.47	11/20
SCHEMBL256320	0.68	10/20
SCHEMBL551454	0.59	10/20
SCHEMBL255668	0.51	10/20
SCHEMBL358342	0.51	10/20
SCHEMBL359261	0.51	10/20
SCHEMBL256859	0.70	9/20

Clinical trials — most relevant to ACACA by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
PCSK9 Inhibitor With Statin Therapy for Asymptomatic Intracranial Atherosclerosis	PHASE4	RECRUITING
Comparison of Coenzyme A and Pantethine Capsule for Safety and Efficacy On Patients With Hyperlipidemia	PHASE3	COMPLETED
Acetylcarnitine and Insulin Sensitivity	PHASE2	COMPLETED
Metabolic Cofactor Supplementation in Obese Patients With Non-Alcoholic Fatty Liver Disease	PHASE2	COMPLETED
Overcoming Primary Resistance to Immunotherapy in Metastatic Melanoma	PHASE2	COMPLETED
Metabolic Cofactor Supplementation in Alzheimer's Disease (AD) and Parkinson's Disease (PD) Patients	PHASE2	COMPLETED
Cholesterol and Inflammation Lowering Via Bempedoic Acid, an ACL-inhibiting Regimen in HIV Trial (CLEAR HIV Trial)	PHASE2	RECRUITING
Comparative Study Between Obeticholic Acid Versus Vitamin E in Patients with Non-alcoholic Steatohepatitis	PHASE2	ACTIVE_NOT_RECRUITING
Preventive Effect of Acetyl-L-carnitine on Oxaliplatin-induced Peripheral Neuropathy	PHASE2	UNKNOWN
Atorvastatin, L-Carnitine and Non-Alcoholic Steatohepatitis	PHASE2	UNKNOWN
The Effects of Coenzyme A on Serum Lipids in Patients With Hyperlipidemia	PHASE2	COMPLETED
Effect of Bezafibrate on Muscle Metabolism in Patients With Fatty Acid Oxidation Defects	PHASE2	COMPLETED
The Effect of Glucagon on Rates of Hepatic Mitochondrial Oxidation in Man Assessed by PINTA	PHASE1	COMPLETED
Safety, Tolerability and Pharmacokinetics of Benfo-Oxythiamine (B-OT) in Healthy Volunteers	PHASE1	COMPLETED
Effects of Experimental Hyperketonemia on Myocardial Metabolism	EARLY_PHASE1	COMPLETED
Lifestyle Intervention in Preparation for Pregnancy (LIPP)	nan	COMPLETED
11C-Acetate PET/CT Non-FDG-Avid Tumors	nan	UNKNOWN
PLatelets Acetyl-CoA Carboxylase Phosphorylation State in SEPtic Shock	nan	COMPLETED
Hepatic Energy Fluxes in NASH and NAS Patients	nan	ACTIVE_NOT_RECRUITING
Effects of Ketones on Muscle Wasting During Caloric Restriction in Lean Females	nan	COMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
Effect of Cocoa Polyphenols Supplementation on Cardiovascular Risk of Postmenopausal Women	nan	UNKNOWN
Influence of WNT4 VEZT FSHB and SIRT1 SNPs in Endometriosis: a Case Control Study of the Sardinian Population	nan	UNKNOWN
Fish Oil and Nonalcoholic Fatty Liver Disease (NAFLD) Study	nan	COMPLETED
Diet Induced Ketosis for Brain Injury - A Feasibility Study	nan	COMPLETED
Novel Inhibitors of Lipolysis in the Treatment of Lipid a Glucose Metabolism in Obstructive Sleep Apnea Syndrome	nan	UNKNOWN
Carnitine Supplementation in Type 2 Diabetic Patients	nan	COMPLETED
Intestinal Ketone Bodies Interfere With the Glycemic Control	nan	COMPLETED
Effect of Omega-3 Fatty Acids Supplementation on Hypertriglyceridemia in Pediatric Patients With Obesity.	nan	COMPLETED
Acute Effect of Fructose on Lipid Metabolism and Gender Differences	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a ACACA binder may also engage these)

Protein	Name	Similarity
Q5SWU9	—	1.000	Q5SWU9 →
P11497	—	1.000	P11497 →
P11029	—	1.000	P11029 →
Q9TTS3	—	1.000	Q9TTS3 →
Q28559	—	1.000	Q28559 →
Q8L5Y9	—	0.974	Q8L5Y9 →
Q923S8	—	0.974	Q923S8 →
Q5R5F8	—	0.973	Q5R5F8 →
Q4R4U1	—	0.972	Q4R4U1 →
Q0J035	—	0.972	Q0J035 →
Q9NVE7	—	0.971	Q9NVE7 →
D2XV59	—	0.971	D2XV59 →
E9Q4Z2	—	0.969	E9Q4Z2 →
Q80YV4	—	0.969	Q80YV4 →
P21343	—	0.969	P21343 →
Q7Z3J2	—	0.967	Q7Z3J2 →
Q5XGS8	—	0.967	Q5XGS8 →
Q5U2U0	—	0.967	Q5U2U0 →
A9JRA0	—	0.966	A9JRA0 →
Q9BPX6	—	0.966	Q9BPX6 →
Q8BWQ6	—	0.966	Q8BWQ6 →
Q5ZLA5	—	0.965	Q5ZLA5 →
Q58DC5	—	0.965	Q58DC5 →
O00178	—	0.965	O00178 →
Q8K2G4	—	0.965	Q8K2G4 →
O09171	—	0.965	O09171 →
A4QNE0	—	0.964	A4QNE0 →
D2SW95	—	0.964	D2SW95 →
A0JN39	—	0.964	A0JN39 →
HELZ	Probable helicase with zinc finger domain	0.964	landscape →