Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 14/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 9/20 | 0.39 |
| ▸ | NRAS | P01111 | 5/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | CDK7 | P50613 | 1/20 | 0.33 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.33 |
| ▸ | CCNH | P51946 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12553544 | 0.86 | FLT3 (0.44) | FLT3IRAK4NRASIRAK1 | |
| SCHEMBL10239089 | 0.85 | FLT3 (0.48) | FLT3IRAK4NRASLCKRET | |
| SCHEMBL10239809 | 0.85 | IRAK4 (0.56) | FLT3IRAK4 | |
| SCHEMBL10238526 | 0.82 | IRAK4 (0.57) | FLT3IRAK4NRASLCKRET | |
| SCHEMBL10239867 | 0.82 | FLT3 (0.47) | FLT3IRAK4NRAS | |
| SCHEMBL13494284 | 0.80 | FLT3 (0.39) | FLT3IRAK4NRASCDK7CCNH | |
| SCHEMBL10239492 | 0.80 | FLT3 (0.39) | FLT3IRAK4NRAS | |
| SCHEMBL10238522 | 0.77 | FLT3 (0.43) | FLT3IRAK4NRAS | |
| SCHEMBL376796 | 0.76 | IRAK4 (0.57) | FLT3IRAK4 | |
| SCHEMBL376547 | 0.76 | IRAK4 (0.57) | FLT3IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2328890-B1 | 6 SUBSTITUTED 2-HETEROCYCLYLAMINO PYRAZINE COMPOUNDS AS CHK-1 INHIBITORS | PFIZER (US) | 2012-01-25 | — | — | EP | disclosed |
| WO-2010016005-A1 | 6 SUBSTITUTED 2-HETEROCYCLYLAMINO PYRAZINE COMPOUNDS AS CHK-1 INHIBITORS | PFIZER INC. (US) | 2010-02-11 | — | — | WO | disclosed |