Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 2/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | NSD2 | O96028 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 2/20 | 0.31 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.31 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
| ▸ | PRKDC | P78527 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10240045 | 0.93 | PIK3CA (0.35) | ALDH1A1PIK3CARAB9ASMN1; SMN2MTOR | |
| SCHEMBL10240036 | 0.91 | KDM4E (0.36) | CYP11B2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10234909 | 0.90 | DYRK1A (0.33) | CYP11B2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10240040 | 0.87 | HSP90AA1 (0.38) | CYP11B2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10240146 | 0.86 | MTOR (0.41) | KDM4EALDH1A1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL10240082 | 0.85 | PDE4A (0.35) | CYP11B2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7886260 | 0.84 | CHEK1 (0.40) | KDM4EALDH1A1RAB9ASMN1; SMN2MTOR | |
| SCHEMBL10240048 | 0.83 | LCK (0.37) | KDM4EALDH1A1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL10234925 | 0.82 | PIK3CA (0.35) | KDM4EALDH1A1PIK3CARAB9ASMN1; SMN2 | |
| SCHEMBL10240053 | 0.82 | CHEK1 (0.34) | MTORRPTORMLST8CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MERCK SHARP & DOHME LLC | 2012-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MTOR, RICTOR, RPTOR | CYP11B2 2145/4885PDE4A 2061/4885PDE4B 1999/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.