Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 3/20 | 0.34 |
| ▸ | RPTOR | Q8N122 | 3/20 | 0.34 |
| ▸ | MLST8 | Q9BVC4 | 3/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PLAU | P00749 | 1/20 | 0.30 |
| ▸ | NSD2 | O96028 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7880980 | 0.90 | HPGD (0.37) | ALDH1A1MTORRPTORMLST8RAB9A | |
| SCHEMBL10234981 | 0.90 | KDM4E (0.35) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL10240036 | 0.87 | KDM4E (0.36) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL10240007 | 0.87 | MTOR (0.45) | MTORRPTORMLST8 | |
| SCHEMBL10240040 | 0.85 | HSP90AA1 (0.38) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL10240035 | 0.85 | CYP11B2 (0.32) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL7885321 | 0.85 | MTOR (0.39) | KDM4EALDH1A1MTORRPTORMLST8 | |
| SCHEMBL10240033 | 0.85 | MTOR (0.39) | MTORRPTORMLST8MAPT | |
| SCHEMBL7876256 | 0.85 | MTOR (0.40) | MTORRPTORMLST8PIK3CA | |
| SCHEMBL10240093 | 0.84 | MTOR (0.38) | MTORRPTORMLST8RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MERCK SHARP & DOHME LLC | 2012-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MTOR, RICTOR, RPTOR | PDE4A 2061/4885PDE4B 1999/4885PDE4C 2501/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.