Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 2/20 | 0.33 |
| ▸ | MTOR | P42345 | 6/20 | 0.32 |
| ▸ | RPTOR | Q8N122 | 4/20 | 0.32 |
| ▸ | MLST8 | Q9BVC4 | 4/20 | 0.32 |
| ▸ | JAK2 | O60674 | 2/20 | 0.32 |
| ▸ | JAK1 | P23458 | 2/20 | 0.32 |
| ▸ | JAK3 | P52333 | 2/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.32 |
| ▸ | CDK2 | P24941 | 4/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.32 |
| ▸ | LCK | P06239 | 2/20 | 0.31 |
| ▸ | HCK | P08631 | 2/20 | 0.31 |
| ▸ | SRC | P12931 | 2/20 | 0.31 |
| ▸ | KDR | P35968 | 2/20 | 0.31 |
| ▸ | ACACB | O00763 | 1/20 | 0.30 |
| ▸ | ACACA | Q13085 | 1/20 | 0.30 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10240142 | 0.85 | MTOR (0.43) | METMTORRPTORMLST8CHEK1 | |
| SCHEMBL10240036 | 0.85 | KDM4E (0.36) | METMTORRPTORMLST8CHEK1 | |
| SCHEMBL10240062 | 0.85 | TMEM97 (0.34) | METMTORRPTORMLST8JAK2 | |
| SCHEMBL10240063 | 0.83 | MTOR (0.35) | METMTORRPTORMLST8CHEK1 | |
| SCHEMBL10240059 | 0.83 | MAPK1 (0.37) | METMTORRPTORMLST8CHEK1 | |
| SCHEMBL10240139 | 0.81 | RET (0.36) | METMTORRPTORMLST8JAK2 | |
| SCHEMBL10240055 | 0.81 | MET (0.34) | METMTORRPTORMLST8CHEK1 | |
| SCHEMBL10240057 | 0.80 | GRM5 (0.39) | METMTORRPTORMLST8CHEK1 | |
| SCHEMBL10240005 | 0.78 | MTOR (0.42) | MTORRPTORMLST8JAK1CHEK1 | |
| SCHEMBL10240038 | 0.76 | MTOR (0.34) | MTORRPTORMLST8CHEK1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MERCK SHARP & DOHME LLC | 2012-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MTOR, RICTOR, RPTOR | MET 1965/4885MTOR 1/4885RPTOR 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.