Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 4/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.42 |
| ▸ | CDK2 | P24941 | 3/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.38 |
| ▸ | MTOR | P42345 | 3/20 | 0.37 |
| ▸ | RPTOR | Q8N122 | 3/20 | 0.37 |
| ▸ | MLST8 | Q9BVC4 | 3/20 | 0.37 |
| ▸ | HPGDS | O60760 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 3/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 2/20 | 0.34 |
| ▸ | KIF5B | P33176 | 2/20 | 0.34 |
| ▸ | ETV6 | P41212 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | CCDC6 | Q16204 | 2/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | BCR | P11274 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10240077 | 0.92 | CHEK1 (0.42) | CHEK1CCNA2CDK2CCNA1HTR2B | |
| SCHEMBL10234950 | 0.89 | CHEK1 (0.41) | CHEK1CCNA2CDK2CCNA1HTR2B | |
| SCHEMBL10240016 | 0.87 | MTOR (0.42) | CHEK1CCNA2CDK2CCNA1HTR2B | |
| SCHEMBL10240080 | 0.86 | RET (0.40) | KDRRETKIF5BETV6KCNH2 | |
| SCHEMBL10240020 | 0.86 | MTOR (0.42) | CHEK1CCNA2CDK2CCNA1HTR2B | |
| SCHEMBL7881551 | 0.86 | CHEK1 (0.42) | CHEK1CCNA2CDK2CCNA1HTR2B | |
| SCHEMBL10240069 | 0.85 | DPP4 (0.34) | MTORRPTORMLST8KDRRET | |
| SCHEMBL10240014 | 0.84 | MTOR (0.41) | CHEK1CCNA2CDK2CCNA1HTR2B | |
| SCHEMBL10240015 | 0.84 | MTOR (0.41) | CHEK1CCNA2CDK2CCNA1HTR2B | |
| SCHEMBL10234852 | 0.83 | MTOR (0.41) | CHEK1CCNA2CDK2CCNA1HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MERCK SHARP & DOHME LLC | 2012-05-10 | — | — | US | disclosed |
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MERCK SHARP & DOHME LLC | 2012-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MTOR, RICTOR, RPTOR | CHEK1 461/4885CCNA2 2476/4885CDK2 165/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.