Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | MTOR | P42345 | 9/20 | 0.33 |
| ▸ | RPTOR | Q8N122 | 3/20 | 0.33 |
| ▸ | MLST8 | Q9BVC4 | 3/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.32 |
| ▸ | FEN1 | P39748 | 2/20 | 0.32 |
| ▸ | APLNR | P35414 | 2/20 | 0.31 |
| ▸ | MET | P08581 | 2/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.31 |
| ▸ | RET | P07949 | 1/20 | 0.31 |
| ▸ | KIF5B | P33176 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | ETV6 | P41212 | 1/20 | 0.31 |
| ▸ | CCDC6 | Q16204 | 1/20 | 0.31 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10234951 | 0.91 | DPP4 (0.33) | DPP4KCNH2MTORRPTORMLST8 | |
| SCHEMBL10238158 | 0.86 | APLNR (0.32) | DPP4KCNH2MTORRPTORMLST8 | |
| SCHEMBL10240080 | 0.86 | RET (0.40) | KCNH2RETKIF5BKDRETV6 | |
| SCHEMBL10240071 | 0.85 | CHEK1 (0.42) | KCNH2MTORRPTORMLST8RET | |
| SCHEMBL10240062 | 0.79 | TMEM97 (0.34) | MTORRPTORMLST8METPIK3CA | |
| SCHEMBL10240016 | 0.79 | MTOR (0.42) | KCNH2MTORRPTORMLST8RET | |
| SCHEMBL10240059 | 0.78 | MAPK1 (0.37) | MTORRPTORMLST8ALOX5APFEN1 | |
| SCHEMBL10240020 | 0.78 | MTOR (0.42) | KCNH2MTORRPTORMLST8RET | |
| SCHEMBL10240029 | 0.78 | MTOR (0.35) | MTORRPTORMLST8RETKIF5B | |
| SCHEMBL10240077 | 0.77 | CHEK1 (0.42) | KCNH2MTORRPTORMLST8RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MERCK SHARP & DOHME LLC | 2012-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MTOR, RICTOR, RPTOR | DPP4 888/4885KCNH2 4542/4885MTOR 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.