Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 1/20 | 0.47 |
| ▸ | KLK7 | P49862 | 1/20 | 0.46 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 2/20 | 0.46 |
| ▸ | CPB1 | P15086 | 1/20 | 0.45 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3820597 | 0.94 | KLK7 (0.50) | PPARAKLK7KLK5CTSKCPB1 | |
| SCHEMBL375888 | 0.94 | KLK7 (0.50) | PPARAKLK7KLK5CTSKCPB1 | |
| SCHEMBL1021830 | 0.91 | CTSK (0.50) | PPARAKLK7KLK5CTSKMAPT | |
| SCHEMBL4156580 | 0.86 | PPARA (0.53) | PPARAKLK7KLK5CTSKMAPT | |
| SCHEMBL7511111 | 0.86 | KLK7 (0.53) | PPARAKLK7KLK5CTSKMAPT | |
| Hydrochloric Acid SCHEMBL26119693 | 0.85 | KLK7 (0.52) | PPARAKLK7KLK5CTSKMAPT | |
| Lysine SCHEMBL11588304 | 0.84 | ECE1 (0.48) | PPARAKLK7KLK5CPB1CPB2 | |
| Lysine SCHEMBL29140134 | 0.83 | ACE (0.60) | PPARACTSKITGB3ITGA2B | |
| SCHEMBL1022361 | 0.83 | PRSS1 (0.52) | KLK7KLK5CTSKITGB3ITGA2B | |
| SCHEMBL4514316 | 0.82 | SIRT2 (0.55) | KLK7KLK5CTSKCPB1CPB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797110-B1 | ANTIBACTERIAL AMIDE MACROCYCLES IV | AICURIS GMBH & CO KG (DE) | 2011-01-12 | — | — | EP | disclosed |