Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 5/20 | 0.41 |
| ▸ | NOS1 | P29475 | 4/20 | 0.41 |
| ▸ | NOS3 | P29474 | 2/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 5/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.38 |
| ▸ | CCNK | O75909 | 1/20 | 0.38 |
| ▸ | CDK7 | P50613 | 1/20 | 0.38 |
| ▸ | CCNH | P51946 | 1/20 | 0.38 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.38 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10235130 | 0.95 | CCNA2 (0.38) | ALDH1A1SMN1; SMN2LMNAMAPTTSHR | |
| SCHEMBL10239221 | 0.94 | MAP4K4 (0.40) | ALDH1A1SMN1; SMN2LMNAMAPTTSHR | |
| SCHEMBL10235128 | 0.92 | CCNA2 (0.40) | CDK2CCNA2CCNKCDK7CCNH | |
| SCHEMBL10235318 | 0.92 | CCNA2 (0.39) | MAP4K4CDK2CCNA2CCNKCDK7 | |
| SCHEMBL10235323 | 0.91 | CCNA2 (0.39) | ALDH1A1MAPTMAP4K4CDK2CCNA2 | |
| SCHEMBL10235145 | 0.91 | MAPK8 (0.39) | ALDH1A1SMN1; SMN2LMNAMAPTTSHR | |
| SCHEMBL10235148 | 0.91 | CCNA2 (0.38) | ALDH1A1SMN1; SMN2LMNAMAPTTSHR | |
| SCHEMBL10235114 | 0.90 | MET (0.39) | MAP4K4CDK2CCNA2CCNKCDK7 | |
| SCHEMBL10235118 | 0.90 | MAPK8 (0.38) | MAP4K4CDK2CCNA2CCNKCDK7 | |
| SCHEMBL10235119 | 0.90 | CCNA2 (0.38) | MAP4K4CDK2CCNA2CCNKCDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MERCK SHARP & DOHME LLC | 2012-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MTOR, RICTOR, RPTOR | ALDH1A1 3479/4885SMN1; SMN2 1798/4885LMNA 3708/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.