Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 6/20 | 0.73 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.73 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.73 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.73 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.73 |
| ▸ | PI4KA | P42356 | 1/20 | 0.62 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.62 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.62 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.55 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15426678 | 1.00 | ADORA2A (0.73) | ADORA2AADORA3ADORA1ADORA2BCYP2D6 | |
| SCHEMBL9791716 | 1.00 | ADORA2A (0.73) | ADORA2AADORA3ADORA1ADORA2BCYP2D6 | |
| SCHEMBL15425667 | 1.00 | ADORA2A (0.73) | ADORA2AADORA3ADORA1ADORA2BCYP2D6 | |
| SCHEMBL13454924 | 0.91 | PI4KA (0.62) | ADORA2AADORA3ADORA1ADORA2BCYP2D6 | |
| SCHEMBL6664080 | 0.91 | ADORA3 (0.62) | ADORA2AADORA3ADORA1ADORA2BCYP2D6 | |
| SCHEMBL6664072 | 0.91 | ADORA3 (0.62) | ADORA2AADORA3ADORA1ADORA2BCYP2D6 | |
| SCHEMBL15144301 | 0.87 | ADORA3 (0.69) | ADORA2AADORA3ADORA1ADORA2BPI4KA | |
| SCHEMBL12200089 | 0.87 | ADORA3 (0.69) | ADORA2AADORA3ADORA1ADORA2BPI4KA | |
| SCHEMBL7735031 | 0.87 | ADORA3 (0.69) | ADORA2AADORA3ADORA1ADORA2BPI4KA | |
| SCHEMBL5507191 | 0.87 | ADORA3 (0.69) | ADORA2AADORA3ADORA1ADORA2BPI4KA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8183224-B2 | Purine derivatives as adenosine A1 receptor agonists and methods of use thereof | INOTEK PHARMACEUTICALS CORPORATION (US) | 2012-05-22 | — | — | US | disclosed |
| US-20090062314-A1 | Purine derivatives as adenosine A1 receptor agonists and methods of use thereof | INOTEK PHARMACEUTICALS CORPORATION (US) | 2009-03-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090062314-A1 | Purine derivatives as adenosine A1 receptor agonists and methods of use thereof | ADORA2A, ADORA1, ADORA3 | ADORA2A 1/4885ADORA3 3/4885ADORA1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.