ADORA3

Adenosine receptor A3 · P0DMS8 · ADORA3 on Sugi Atlas →

717,381 patent compounds predicted against ADORA3, 486,744 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Nifedipine (SCHEMBL3968)	1.00	7/20
1-Methylxanthine (SCHEMBL10996)	0.64	7/20
SCHEMBL3541	0.56	6/20
SCHEMBL8565	0.40	6/20
Atrimustine (SCHEMBL8659)	0.56	5/20
Xanthine (SCHEMBL4965)	0.41	5/20
Adenosine (SCHEMBL731)	1.00	4/20
Miconazole (SCHEMBL2866)	1.00	4/20
(R)-Miconazole (SCHEMBL2867)	1.00	4/20
Clocortolone Pivalate (SCHEMBL5120)	1.00	4/20
Prochlorperazine (SCHEMBL18429)	1.00	4/20
Miconazole (SCHEMBL3366)	0.98	4/20
(R)-Miconazole (SCHEMBL3367)	0.98	4/20
Vidarabine (SCHEMBL2929)	0.97	4/20
Theophylline Anhydrous (SCHEMBL4915)	0.96	4/20
Estramustine Phosphate (SCHEMBL19436)	0.86	4/20
Miconazole (SCHEMBL15799)	0.84	4/20
(R)-Miconazole (SCHEMBL15800)	0.84	4/20
Theophylline Anhydrous (SCHEMBL5037)	0.81	4/20
Fludarabine (SCHEMBL4105)	0.67	4/20

Clinical trials — most relevant to ADORA3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Stress Testing and Cardiac Magnetic Resonance	PHASE4	COMPLETED
Allopurinol in Schizophrenia: A Randomized Trial Administering Allopurinol vs Placebo as add-on Antipsychotics in Patients With Schizophrenia	PHASE4	COMPLETED
Regadenoson Blood Flow in Type 1 Diabetes (RABIT1D)	PHASE4	COMPLETED
Ticagrelor in Remote Ischemic Preconditioning Study	PHASE4	COMPLETED
Effects of Caffeine on Reinforcement Learning in Healthy Adults Using PET/MRI	PHASE4	RECRUITING
Ticagrelor And PrEconditioning in Patients With coronaRy Artery diSease	PHASE2/PHASE3	COMPLETED
Preventing Acute Kidney Injury (AKI) in Pediatric Patients	PHASE3	UNKNOWN
Allopurinol for Mania: A Randomized Trial Administering Allopurinol vs. Placebo as add-on to Mood Stabilizers and/or Antipsychotics in Patients in a Bipolar Manic Episode	PHASE3	COMPLETED
Placebo-Controlled Randomized Study of KW-3902 for Subjects Hospitalized With Worsening Renal Function and Heart Failure Requiring IV Therapy	PHASE3	COMPLETED
PROTECT-2: A Study of the Selective A1 Adenosine Receptor Antagonist KW-3902 for Patients Hospitalized With Acute HF and Volume Overload to Assess Treatment Effect on Congestion and Renal Function	PHASE3	COMPLETED
PROTECT-1: A Study of the Selective A1 Adenosine Receptor Antagonist KW-3902 for Patients Hospitalized With Acute HF and Volume Overload to Assess Treatment Effect on Congestion and Renal Function	PHASE3	COMPLETED
Clonidine Versus Adenosine to Treat Neuropathic Pain	PHASE2	COMPLETED
Psychopharmacology for Cocaine Dependence - Buspirone	PHASE2	COMPLETED
KW-6002 to Treat Parkinson's Disease	PHASE2	COMPLETED
Study to Evaluate Adenosine 2A Receptor Agonist (Regadenoson) in Patients Undergoing Lung Transplantation	PHASE1	UNKNOWN
Using PET Scans to Study Brain Receptor Occupancy of BIIB014 in Healthy Male Volunteers	PHASE1	COMPLETED
Occupancy of Adenosine A2A Receptors Using the PET Radiotracer [18F]MNI-444	PHASE1	COMPLETED
Regadenoson Infusion of Marginalized Donor Lungs in an EVLP System	EARLY_PHASE1	COMPLETED
Effects of Aminophylline on Renal Function and Urine Volume of AKI Patient	EARLY_PHASE1	UNKNOWN
Effect of Caffeine on Cold-stimulated Brown Adipose Tissue Activity	nan	RECRUITING
Adenosine and A2A Receptors in Human Brown Adipose Tissue	nan	COMPLETED
Polymorphisms, Caffeine and Sleep Disorders	nan	COMPLETED
Poor Sleep and Inflammation in HIV-Infected Adults	nan	COMPLETED
Determination of Coronarphysiological Parameters With the Method of Thermodillution	nan	COMPLETED
Pilot Study on Caffeine Efficiency in ADCY5-related Dyskinesia	nan	COMPLETED
Effect of Polymorphisms in the Adenosine a2a Receptor Gene and AMPD2 Gene on Adenosine-Induced Vasodilation and Reactive Hyperemia	nan	COMPLETED
Genetic Causes of Panic Disorder	nan	COMPLETED
Sublingual Caffeine on Reducing Recovery Time and Postoperative Agitation in Elderly Patients Undergoing General Anesthesia	nan	RECRUITING
Motivational, Affective and Performance Effects of Caffeine Supplementation	nan	UNKNOWN
The Effect Of Coffee And Tea Drink On Gis Functions Healing Quality After Surgery in Patients Surgery	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a ADORA3 binder may also engage these)

Protein	Name	Similarity
Q28309	—	1.000	Q28309 →
P28647	—	1.000	P28647 →
Q0VC81	—	0.999	Q0VC81 →
Q61618	—	0.999	Q61618 →
P35342	—	0.998	P35342 →
O02667	—	0.996	O02667 →
P49892	—	0.986	P49892 →
Q60612	—	0.981	Q60612 →
P25099	—	0.975	P25099 →
P47745	—	0.974	P47745 →
P28190	—	0.972	P28190 →
P34970	—	0.972	P34970 →
Q5RF57	—	0.971	Q5RF57 →
ADORA1	Adenosine receptor A1	0.967	landscape →
P79945	—	0.966	P79945 →
Q923X9	—	0.964	Q923X9 →
O13076	—	0.964	O13076 →
Q5QD12	—	0.963	Q5QD12 →
Q96RI9	—	0.963	Q96RI9 →
Q9DDK4	—	0.963	Q9DDK4 →
Q5QD10	—	0.961	Q5QD10 →
Q6W3F4	—	0.961	Q6W3F4 →
Q923Y0	—	0.961	Q923Y0 →
Q969N4	—	0.961	Q969N4 →
Q5W8W0	—	0.961	Q5W8W0 →
Q5QD06	—	0.960	Q5QD06 →
O02835	—	0.960	O02835 →
P35382	—	0.960	P35382 →
P11616	—	0.960	P11616 →
Q56H79	—	0.960	Q56H79 →