⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11095717 | 0.85 | — | — | |
| SCHEMBL3977371 | 0.81 | — | — | |
| SCHEMBL5932768 | 0.79 | — | — | |
| SCHEMBL19004724 | 0.78 | TSHR (0.40) | — | |
| SCHEMBL109285 | 0.78 | TSHR (0.40) | — | |
| SCHEMBL3836543 | 0.78 | — | — | |
| SCHEMBL8395179 | 0.77 | — | — | |
| SCHEMBL10002586 | 0.76 | — | — | |
| SCHEMBL28385524 | 0.73 | — | — | |
| SCHEMBL3833969 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1117 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104974109-B | Propine amide derivatives and its preparation method and pharmaceutical composition and purposes containing thiazole | 中国医学科学院药物研究所 | 2019-10-01 | — | — | CN | claimed |
| CN-104974109-A | Propynamide derivatives containing thiazole as well as preparation method, drug composition and application thereof | INST MATERIA MEDICA CAMS | 2015-10-14 | — | — | CN | claimed |
| CN-104974104-A | Propynamide derivatives containing oxazole as well as preparation method, drug composition and application thereof | INST MATERIA MEDICA CAMS | 2015-10-14 | — | — | CN | claimed |
| WO-2009129371-A1 | CATHEPSIN C INHIBITORS | GLAXO GROUP LIMITED (GB) | 2009-10-22 | — | — | WO | claimed |
| US-20090264499-A1 | Cathepsin C Inhibitors | GLAXO GROUP LIMITED (GB) | 2009-10-22 | — | — | US | claimed |
| EP-1575947-A1 | 2-OXOPYRIDIN-3-YL THIA(DI)AZOLE DERIVATIVES FOR USE IN THE TREATMENT OF CELL PROLIFERATION AND APOPTOSIS RELATED DISEASES | Amgen Inc. (US) | 2005-09-21 | — | — | EP | claimed |
| WO-2004060890-A1 | 2-OXOPYRIDIN-3-YL THIA (DI) AZOLE DERIVATES FOR USE IN THE TREATMENT OF CELL PROLIFERATION AND APOPTOSIS RELATED DISEASES | AMGEN INC. (US) | 2004-07-22 | — | — | WO | claimed |
| EP-0582790-B1 | Novel method of producing 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines | AMERICAN CYANAMID CO (US) | 1998-12-23 | — | — | EP | claimed |
| EP-3594282-B1 | RUBBER COMPOSITION AND TIRE | OTSUKA CHEMICAL CO LTD (JP) | 2024-07-17 | — | — | EP | disclosed |
| CN-112912139-B | Biaryl derivatives | 第一三共株式会社 | 2024-07-09 | — | — | CN | disclosed |
| WO-2024140700-A1 | BENZOTHIAZOLE COMPOUND, AND SYNTHESIS THEREFOR AND USE THEREOF | 西北农林科技大学 | 2024-07-04 | — | — | WO | disclosed |
| WO-2024135828-A1 | AVERMECTIN DERIVATIVE | Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 | 2024-06-27 | — | — | WO | disclosed |
| US-12018267-B2 | Plants having increased tolerance to herbicides | BASF SE (DE) | 2024-06-25 | — | — | US | disclosed |
| CN-118206569-A | Azoline ammonium quinoline carboxamide analogue, pharmaceutical composition, preparation method and medical application thereof | 上海市针灸经络研究所 | 2024-06-18 | — | — | CN | disclosed |
| US-5068222-A | Polypeptides for treatment of cancer | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-11-26 | — | — | US | disclosed |
| EP-0453883-A2 | 2-amino-4-trichloropyridine derivatives | BASF Aktiengesellschaft (DE) | 1991-10-30 | — | — | EP | disclosed |
| EP-0421441-A2 | Pantothenic acid derivatives | FUJIREBIO INC. (JP) | 1991-04-10 | — | — | EP | disclosed |
| EP-0345990-A2 | Polypeptide compounds | ZENECA LIMITED (GB) | 1989-12-13 | — | — | EP | disclosed |
| EP-0315367-A2 | Polypeptides | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-05-10 | — | — | EP | disclosed |
| US-4545804-A | HERBICIDES | MONSANTO COMPANY (US) | 1985-10-08 | — | — | US | disclosed |